摘要
异柠檬酸脱氢酶(isocitrate dehydrogenase,IDH)基因突变存在于70%~80%的Ⅱ~Ⅲ级胶质瘤和90%的继发性胶质母细胞瘤。越来越多的研究表明,IDH基因突变与胶质瘤的发生、生物学行为、临床表现及预后相关。IDH基因型作为新的生物标志物,在胶质瘤精确诊断、疗效评估、临床决策等方面发挥重要作用。当前检测胶质瘤IDH基因的方法主要包括有创性免疫组化和基因测序。近年来,随着多模态MRI的发展,影像学研究已深入到影像基因组学和遗传学领域,以影像手段实现IDH基因型的术前无创评估对脑胶质瘤个体化精准诊疗具有重要意义,有关磁共振功能成像术前评价胶质瘤患者IDH基因型的研究也日益增多。笔者简要概述脑胶质瘤中IDH突变及其临床意义,并对近年来磁共振功能成像预测脑胶质瘤IDH基因型的研究进展进行综述。
IDH gene mutations exist in 70%-80% of grade Ⅱ-Ⅲ gliomas and 90% of secondary glioblastomas.Growing data indicate that IDH mutations play prominent roles in the occurrence of glioma,biological behavior,and also have clinical and prognostic importance.At the same time,IDH genotypes as an important biomarker can help to find possible targets for the treatment of glioma and achieve accurate diagnosis or treatment of tumors.Current methods for detecting glioma IDH genes include invasive immunohistochemistry and genetic testing.In recent years,with the development of multimodal MRI,imaging studies have penetrated into the fields of radiomics and radiogenomics.The preoperative non-invasive evaluation of IDH genotype by imagings is of great significance for the individualized accurate diagnosis and treatment of glioma. Researchers have explored the link between imaging features and tumor gene phenotypes. Functional magnetic resonance imaging is increasingly used for preoperative detection of IDH genotype in glioma.This paper will summarize the IDH mutations in gliomas and will review recent progress of noninvasive assessment IDH genotype in glioma by functional magnetic resonance imaging.
作者
闫海丽
张辉
YAN Haili;ZHANG Hui(Department of Medical Imaging,Shanxi Medical University,Taiyuan 030001,China;Department of Radiology,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《磁共振成像》
CAS
2019年第6期452-455,共4页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:81771824,81471652)
山西省重点研发计划社会发展项目(编号:201703D321016)~~
