摘要
急性肾损伤(AKI)是以肾功能短期内急剧下降为特征的临床综合征。近年来,AKI的发病率逐渐增高。患者一旦发生AKI,短期内可显著延长住院时间、增加住院费用和住院病死率,远期后果包括AKI复发进而发展为慢性肾脏病(CKD )、终末期肾病(ESRD)、心血管事件及死亡等。缺血/再灌注(1/R)损伤和造影剂是引起AKI的常见原因。I/R损伤和造影剂诱导的肾病与钠钙交换体(NCX)引发的细胞内钙超载有关。现就NCX与AKI的关系进行综述,希望为AKI的防治及改善预后提供帮助。
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline of renal function in a short period of time. In recent years, the incidence of AKI has been increasing gradually. Once the AKI occurs in a patient whose mortality in hospital may be increased significantly, the length of stay in hospital will be prolonged and the hospitalization costs increased in a short term, the long-term consequences include AKI recurrence, development into chronic kidney disease (CKD) or end-stage kidney disease (ESRD), cardiovascular events and death, etc. Ischemia/ reperfusion (I/R) injury and contrast agents are common causes of AKI. The nephropathy induced by I/R and contrast agent is associated with intracellular calcium overload caused by Na -Ca~ exchanger (NCX). In this article, a systematic review of the relationship between NCX and AKI was conducted, aiming to provide a reference for further recognizing the prevention, treatment and prognosis of AKI.
作者
王维秀
陈莎
杨定位
Wang Weixiu;Chen Sha;Yang Dingwei
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2019年第2期251-253,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
天津市自然科学基金(16JCYBJC25600).
