摘要
目的探究盐酸乙哌立松联合水疗治疗老年膝关节骨性关节炎(OA)的疗效。方法选取2016年7月至2017年7月收治的老年膝关节OA患者124例,按随机数字表法分为两组,各62例。对照组采用玻璃酸钠关节腔内注射治疗,5ml/次,1次/d。观察组采用口服盐酸乙哌立松(每次50mg,每天3次)联合水疗治疗(温水浴中进行膝关节活动训练,每次60min)。两组均治疗2个月。对比两组治疗前后西安大略和麦克马斯特大学(WOMAC)关节炎指数评分、OA严重指数(ISOA)评分、Ⅱ型胶原C端肽(CTX-Ⅱ)水平。结果两组治疗1个月、2个月后关节疼痛、关节僵硬、活动难度评分及总分均明显低于治疗前(P<0.05),且观察组低于对照组(P<0.01);两组治疗1个月、2个月后ISOA评分均明显低于治疗前(P<0.05),且观察组低于对照组(P<0.01);两组治疗1个月、2个月后CTX-Ⅱ水平均明显低于治疗前(P<0.05),且观察组低于对照组(P<0.01)。结论对老年膝关节骨性关节炎采用盐酸乙哌立松联合水疗治疗,临床疗效优于玻璃酸钠关节腔内注射治疗,有利于促进关节软骨恢复。
Objective To investigate the efficacy of eperisone hydrochloride combined with hydrotherapy in the treatment of elderly patients with knee osteoarthritis(OA).Methods A total of 124 elderly patients with knee OA admitted to hospital from July 2016 to July 2017 were randomly divided into observation group and control group(n=62,each).The sodium hyaluronate was given in control group,and the eperisone hydrochloride combined with hydrotherapy was performed in observation group.The changes of Western Ontario and McMaster Universitiy(WOMAC) arthritis indexes,index of severity for OA(ISOA)and C-terminal crosslinking telopeptide of collagen type Ⅱ(CTX-Ⅱ) content before and after treatment were compared between two groups.Both groups were treated for 2 months.Results After 1-and 2-month of treatment,the scores of joint pain,joint stiffness,dysfunction and total score were significantly lower in two groups than those before treatment(P<0.05),and were lower in observation group than those in control group(P< 0.01);the ISOA was significantly lower than that before treatment(P<0.05) in both groups,and was lower in the observation group than in the control group(P<0.01);the level of CTX-Ⅱ in two groups was significantly lower than that before treatment(P<0.05),and was lower in observation group than that in the control group(P<0.01).Conclusion For elderly knee OA treated with eperisone hydrochloride combined with hydrotherapy,the clinical effect is better than intra-articular injection of sodium hyaluronate,which is beneficial to promote the recovery of articular cartilage.
作者
席佳韵
苏敏
王颖
宝金才
许钰
戴进
XI Jia-yun;SU Min;WANG Ying;BAO Jin-cai;XU Yu;DAI Jin(Department of Rehabilitation ,The First Affiliated Hospital of Suzhou University,Suzhou,Jiangsu 215006,China)
出处
《中国临床研究》
CAS
2019年第5期616-619,共4页
Chinese Journal of Clinical Research
基金
国家自然科学基金(81672239)~~
