摘要
目的探讨妊娠女性血栓弹力图(TEG)各项指标的动态变化特点。方法2018年1~11月在柳州市中医医院进行产检和分娩住院的孕妇150例为妊娠组,根据孕龄不同分为早孕组(47例)、中孕组(53例)、晚孕组(50例),将未孕育龄女性50例设为对照组。检测并比较对照组、妊娠组不同妊娠时期以及产后不同时期的TEG参数、常规凝血指标。结果妊娠组R值、K值明显低于对照组,Angle角、MA值明显高于对照组,差异有高度统计学意义(P<0.01)。中孕组、晚孕组的R值、K值均明显低于早孕组,Angle角、MA值均明显高于早孕组,差异有统计学意义(P<0.05或P<0.01)。晚孕组的K值明显低于中孕组,差异有高度统计学意义(P<0.01)。产后各时间点的R值、K值、Angle角、MA值比较,差异均有高度统计学意义(P<0.01)。随着产后时间的进展,R值、K值呈渐进性升高,Angle角、MA值呈渐进性减低。妊娠组组间APTT、纤维蛋白原、Ti比较差异均有高度统计学意义(P<0.01)。结论妊娠不同时期、产后不同时期的TEG各项指标存在相应的变化,能够动态的反映出的凝血功能改变。
Objective To explore the dynamic change characteristics of thromboelastogram in pregnancy women′s.Methods From January to November 2018,a total of 150 pregnant women who were admitted to Liuzhou Traditional Chinese Medicine Hospital were in the pregnancy group,which were divided into the early pregnancy group(n=47),the middle pregnancy group(n=53)and the late pregnancy group(n=50)according to the gestational week.The control group included 50 women who were not pregnant.TEG parameters and routine blood coagulation indexes were measured and compared among the control group,pregnancy group,and the postpartum period.Results The R and K values of the pregnancy group were significantly lower than those of the control group,while the Angle and MA values were significantly higher than those of the control group,with highly statistically significant differences(P<0.01).The R and K values of the middle and late pregnancy group were significantly lower than those of the early pregnancy group,while the Angle and MA values were significantly higher than those of the early pregnancy group,with statistically significant differences(P<0.05 or P<0.01).The K value of the late pregnancy group was significantly lower than that of the middle pregnancy group,and the difference was highly statistically significant(P<0.01).There were highly significant statistical differences in R,K,Angle and MA values at all postpartum time points(P<0.01).With the development of postpartum time,R value and K value gradually increased,while Angle and MA value gradually decreased.There were highly statistically significant differences in ATPP,fibrinogen and Ti between pregnant groups(P<0.01).Conclusion The indicators of TEG at different stages of pregnancy and postpartum have corresponding changes,which can reflect the changes of coagulation function dynamically.
作者
李华
阳建伶
马兴璇
唐石伏
刘适
简洁
李雅倩
冉进秋
LI Hua;YANG Jianling;MA Xingxuan;TANG Shifu;LIU Shi;JIAN Jie;LI Yaqian;RAN Jinqiu(Department of Laboratory,Liuzhou Traditional Chinese Medicine Hospital,Guangxi Zhuang Autonomous Region,Liuzhou 545001,China;Department of Laboratory,Hu′nan Provincial People′s Hospital,Hu′nan Province,Changsha 410005,China;Department of Obstetrics,Liuzhou Traditional Chinese Medicine Hospital,Guangxi Zhuang Autonomous Region,Liuzhou 545001,China;Guilin Medical University,Guangxi Zhuang Autonomous Region,Guilin 541000,China)
出处
《中国医药导报》
CAS
2019年第14期75-78,共4页
China Medical Herald
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180383)
关键词
妊娠
血栓弹力图
凝血功能
动态变化
Pregnancy
Thromboelastogram
Blood coagulation function
Dynamic change
