摘要
目的观察不同剂量瑞舒伐他汀对老年冠心病合并糖尿病患者脂代谢与同型半胱氨酸水平的影响。方法选取北京市海淀医院2016年5月~2017年5月收治的老年糖尿病合并冠心病患者100例,按照随机数字表法将其分为对照组和观察组,每组各50例。对照组口服低剂量瑞舒伐他汀片10 mg/次,1次/d,观察组口服高剂量瑞舒伐他汀片20 mg/次,1次/d,疗程均为6个月。观察两组患者治疗前、治疗后1、6个月总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、同型半胱氨酸(Hcy)及治疗前后血浆纤维蛋白原(Fg)水平。结果治疗前两组患者TG、TC、LDL-C、HDL-C、Hcy、Fg比较,差异无统计学意义(P>0.05)。治疗后1、6个月两组TG、TC、LDL-C、Hcy均较治疗前降低,且观察组TG、TC、LDL-C、Hcy水平均低于对照组(P<0.05)。治疗后1、6个月两组患者HDL-C均升高,观察组高于对照组(P<0.05)。两组患者治疗后1、6个月Fg降低,且观察组低于对照组(P<0.05)。结论大剂量瑞舒伐他汀能更有效控制老年冠心病合并糖尿病患者的血脂、Fg和Hcy水平。
Objective To observe the effects of different doses of rosuvastatin on lipid metabolism and homocysteine levels in elderly patients with coronary heart disease and diabetes mellitus. Methods From May 2016 to May 2017, 100 elderly patients with diabetes mellitus and coronary heart disease admitted to Beijing Haidian Hospital were selected and divided into control group and observation group according to the random number table method, with 50 cases in each group. The control group received low-dose Risuvastatin Tablets at 10 mg/time and once a day, while the observation group received high-dose Risuvastatin Tablets at 20 mg/time and the course of treatment was 6 months. Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), homocysteine (Hcy) and plasma fibrinogen (Fg) levels before and after treatment were observed in the two groups. Results Before treatment, TG, TC, LDL-C, HDL-C, Hcy and Fg of the two groups were compared, and the differences were not statistically significant (P > 0.05). At 1,6 months after treatment, TG, TC, LDL-C and Hcy in the two groups were all decreased. The levels of TG, TC, LDL-C and Hcy in the observation group were lower than those in the control group at 1 month and 6 months after treatment (P<0.05). HDL-C increased in both groups 1,6 months after treatment, and was higher in the observation group than the control group (P<0.05). Fg was decreased in the two groups 1,6 months after treatment, and the observation group was lower than that in the control group (P<0.05). Conclusion Large dose of Rosuvastatin can effectively control blood lipid, Fg and Hcy levels in elderly patients with coronary heart disease and diabetes mellitus.
作者
陈卫平
CHEN Weiping(Department of Geriatrics, Beijing Haidian Hospital, Beijing 100080, China)
出处
《中国医药导报》
CAS
2019年第13期155-158,共4页
China Medical Herald
关键词
瑞舒伐他汀
冠心病
糖尿病
血脂
同型半胱氨酸
Rosuvastatin
Coronary heart disease
Diabetes
Blood lipid
Homocysteine
