摘要
目的分析结核性脑(膜)炎(简称结脑)和隐球菌性脑(膜)炎(简称隐脑)的临床特点,为鉴别这两种疾病提供参考依据。方法对2015年1月~2017年12月收治的52例结脑和30例隐脑患者的临床资料进行回顾性分析。数据分析采用SPSS16.0软件。结果隐脑患者HIV感染率、恶心呕吐发生率、视物模糊发生率均高于结脑。与结脑比较,隐脑患者脑压力升高更显著,脑脊液糖下降更明显,并且当脑脊液蛋白在401~1000mg/L、脑脊液白细胞数<50×10~6/L时,隐脑更为常见。相反,与隐脑比较,当脑脊液蛋白> 2000mg/L、脑脊液白细胞数在(50~500)×10~6/L时,结脑更为常见,差异有统计学意义(P <0.05)。结论可以结合临床表现、合并症、脑压力、脑脊液检查等来鉴别结脑和隐脑。
Objective To analyze the clinical features of tuberculous meningitisand cryptococcal meningitis and to provide reference for the identification of these two diseases. Methods Clinical data of 52 patients with tuberculous meningitis and 30 patients withcryptococcal meningitis who were admitted and treated in our hospital from January 2015 to December 2017 were retrospectively and statistically analyzed by SPSS 16.0. Results The incidence of HIV infection,nausea and vomiting and blurred vision in patients with cryptococcal meningitis were higher than those withtuberculous meningitis.Compared with tuberculous meningitis,the brain pressure of cryptococcal meningitiswas more significantlyimproved and the cerebrospinal fluidglucose was more significantly decreased.When the cerebrospinal fluid protein was 401 to 1000 mg/L and the white blood cell countof cerebrospinal fluid was less than 50×10~6/L,cryptococcal meningitis was more common.Instead,compared withcryptococcal meningitis,tuberculous meningitis was more comman when cerebrospinal fluid protein was more than 2000 mg/L and the white blood cell count of cerebrospinal fluid was(50-500)×10~6/L.All the above differences were statistically significant(P < 0.05).Conclusion Combination of clinical manifestations,complications,brain pressure,cerebrospinal fluid examination can be used to identify tuberculous meningitis and cryptococcal meningitis.
作者
张华敏
刘娜
邓巧娟
ZHANG Huamin;LIU Na;DENG Qiaojuan(Department of Infectious Disease,the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)
出处
《中国医药科学》
2019年第10期15-18,共4页
China Medicine And Pharmacy
