摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种常见的神经系统变性性疾病。氧化应激在AD疾病发生与发展中起着重要作用,从健康人到AD疾病中,抗氧化系统与氧化系统失衡逐渐加重,调节氧化应激水平对AD疾病的进程有积极的意义。中药及复方可通过提高体内抗氧化酶活性,减少自由基生成,来减少Aβ聚集,从而减轻炎症反应及细胞毒性。本文通过综述中药及复方减少AD氧化损伤的研究进展,为临床防治AD提供依据。
Alzheimer’s disease(AD) is a common neurodegenerative disease in nervous system. Oxidative stress plays an important role in the occurrence and development of AD. From healthy people to AD patients, the imbalance of antioxidant system and oxidation system is gradually increasing. It is of positive significance to regulate the level of oxidative stress to the process of AD. Traditional Chinese Medicine and compound can reduce the accumulation of Aβ by increasing the activity of antioxidant enzymes in the body and reducing the formation of free radicals, thus reducing the inflammatory reaction and cycotoxicity. In this paper, we reviewed the research progress of Chinese medicine and compound prescription to reduce oxidative damage, and provided evidence for clinical prevention and treatment of AD.
作者
王琳琳
胡镜清
张治国
江丽杰
王传池
杨燕
Wang Linlin;Hu Jingqing;Zhang Zhiguo;Jiang Lijie;Wang Chuanchi;Yang Yan(Shanxi University of Chinese Medicine First Clinical Medical College,Xianyang 712046,China;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medicine Science,Beijing 100700.China;Hubei University of Chinese Medicine,Wuhan 430065,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2019年第1期38-43,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
中国中医科学院基本科研业务费自主选题(YZ-1818):加味四妙勇安汤对Aβ25-35致海马神经元损伤的保护作用
负责人:王琳琳
关键词
阿尔茨海默病
氧化应激
抗氧化
中药
复方
研究进展
综述
Alzheimer’s disease
oxidative stress
antioxidant
Chinese herbs
compound prescriptions
research progress
overview
