摘要
目的:探讨新斯的明联合生物反馈对产后盆底功能障碍致尿潴留患者尿动力学及盆底肌肉收缩力的影响。方法:产后盆底功能障碍致尿潴留患者116例随机分为2组,每组58例。对照组在常规治疗基础上加以新斯的明治疗,观察组在对照组基础上再加用生物反馈治疗。对比两组患者疗效、尿动力学参数、盆底肌肉收缩力、性生活质量及不良反应发生情况。结果:观察组总有效率为89. 66%,明显高于对照组的70. 69%(P <0. 05)。干预后两组患者最大逼尿肌收缩压及残余尿量均明显下降,盆底肌最大电压值及盆底肌平均电压值,性生活质量量表得分等均明显升高,差异均有统计学意义(P <0. 05);且上述指标观察组均明显优于对照组(P <0. 05)。两组不良反应发生率差异无统计学意义(P> 0. 05),不良反应经停药或使用阿托品后均得到控制。结论:新斯的明联合生物反馈较单独使用新斯的明可明显提高产后盆底功能障碍致尿潴留患者疗效,改善患者尿动力学指标、提高盆底肌肉收缩力、改善患者性生活质量,不增加不良反应发生率。
Objective:To investigate the effects of neostigmine combined with biofeedback on urodynamics and pelvic floor muscle contractility in patients with urinary retention caused by postpartum pelvic floor dysfunction.Methods:A total of 116 patients with urinary retention due to postpartum pelvic dysfunction were divided into 2 groups using a random number table method with 58 cases in each group.The control group was treated with neostigmine on the basis of the conventional treatment,and the observation group was treated with biofeedback on the basis of the control group.The efficacy,urodynamic blood parameters,pelvic floor muscle contractility,quality of sexual life and adverse reactions were compared between the groups.Results:The total effective rate of the observation group was 89.66%,which was significantly higher than that(70.69%)of the control group(P<0.05).After the intervention,the maximum detrusor systolic pressure and residual urine volume of the two groups were significantly decreased,the maximum voltage value of pelvic floor muscle and the average pelvic floor muscle pressure,the scores of the sexual life of the two groups were all significantly increased(P<0.05);and those above indexes in the observation group were all significatntly better than those in the controll group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05),and the patients with adverse reactions were controlled after drug withdrawal or use of atropine.Conclusion:Neostigmine combined with biofeedback can significantly improve postpartum pelvic floor dysfunction,urodynamics,pelvic floor muscle contractility and quality of sexual life without increasing the incidence of adverse reactions in patients with urinary retention.
作者
何泉江
刘晓芳
卢白玉
黎培培
He Quanjiang;Liu Xiaofang;Lu Baiyu;Li Peipei(Suining Central Hospital,Sichuan Suining 629000,China)
出处
《中国药师》
CAS
2019年第5期873-876,共4页
China Pharmacist
基金
四川省卫生和计划生育委员会科研课题(编号:16PJ528)
关键词
新斯的明
生物反馈
产后盆底功能障碍
尿潴留
尿动力学参数
盆底肌肉收缩力
Neostigmine
Biofeedback
Postpartum pelvic dysfunction
Urinary retention
Urodynamic parameters
Pelvic floor muscle contractility
