摘要
目的:探讨防治恶性肿瘤患者化疗后恶心呕吐的经皮透药方,为后期开展相关临床试验研究提供前期基础。方法:通过文献研究,选取8种目前学者关注度较高且确认口服有效的常用止呕方,并制定专家咨询表,采用德尔菲法进行2轮专家咨询。结果:2轮专家咨询,问卷有效回收率为100%,专家权威系数(Cr)分别为0.780和0.803,均大于0.70,表明专家权威性高。第2轮专家咨询,变异系数(CV)为0.091～0.215,Kendall协调系数(W)为0.354,Ρ<0.001,说明专家意见协调、可靠。8种止呕方中专家对于选取小半夏汤意见最为集中,变异系数最小,选定比例达45%。结论:最终确定小半夏汤为最佳经皮透药方来进行后续研究。
Objective: To explore the transdermal prescriptions for the prevention and treatment of nausea and vomiting after chemotherapy in patients with malignant tumor, to provide basis for conducting relevant clinical trial research in the later stage. Methods: Through literature research, eight kinds of commonly used antiemetic prescriptions with high attention and effective oral administration were selected. Expert consultation tables were made and two rounds of expert consultation were carried out by Delphi method. Results: In the two rounds of expert consultation, the effective recovery rate of the questionnaire was 100%, and the expert authority coefficient (Cr) was 0.780 and 0.803, respectively, which were greater than 0.70, indicating that the expert authority was high. In the second round of expert consultation, the coefficient of variation (CV) was 0.091~0.215, Kendall's coordination coefficient (W) was 0.354, P <0.001, which showed that expert opinions were coordinated and reliable. Among the eight antiemetic prescriptions, experts have the most concentrated opinions on the selection of Xiaobanxia Decoction (小半夏汤), with the lowest coefficient of variation (CV) of 45%. Conclusion: Finally, Xiaobanxia Decoction is determined to be the best transdermal prescription for follow-up study.
作者
方森
陈燕
FANG Sen;CHEN Yan(College of Nursing,Hu'nan University of Chinese Medicine,Changsha Hu'nan 410208,China;The Affiliated Hospital of Hu'nan Academy of Chinese Medicine,Changsha Hu'nan 410006,China)
出处
《中医药导报》
2019年第8期41-44,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
湖南中医药大学老年肿瘤护理研究生培养创新基地(校行研字[2015]12号)
湖南省高层次卫生人才"225"工程项目(湘卫人发[2013]13号)
关键词
恶性肿瘤
化疗相关性恶心呕吐
经皮透药方
德尔菲法
malignant neoplasms
chemotherapy -associated nausea and vomiting
transdermal prescription
Delphi method
