摘要
目的:观察补肾化痰方辨证治疗多囊卵巢综合征患者的临床效果。方法:选取从2015年2月—2017年3月在本院妇产科不孕症专科诊断为多囊卵巢综合征的患者共90例,按数字随机表法分为观察组与对照组,每组45例。所有患者从月经第5d开始给予来曲唑进行治疗,观察组在对照组基础上联合补肾化痰方进行治疗。观察检测两组患者治疗前后子宫内膜厚度和卵巢体积,对患者痤疮症状及月经失调进行评分,并计算排卵率及妊娠率;测定治疗前后卵泡刺激素(folliclestimulating hormone,FSH)、黄体生成素(luteotropic hormone,LH)、雌二醇(estradiol,E2)、睾酮(testosterone,T)及催乳素(prolactin,PRL)水平。结果:观察组治疗后卵巢体积、痤疮评分、月经失调评分明显低于对照组(P <0. 05);子宫内膜厚度与对照组比较无明显差异。观察组排卵率显著高于对照组(P <0. 05);妊娠率略高于对照组,但无统计学差异(P> 0. 05)。观察组治疗后卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)、泌乳素(PRL)水平明显降低(P <0. 05);且治疗后,观察组生殖激素水平明显低于对照组,两组比较有统计学差异(P <0. 05)。结论:补肾化痰方联合来曲唑能有效促进多囊卵巢综合征患者排卵,并改善其卵泡刺激素及黄体生成素等生殖激素水平。
Objective: To study the effect of Bushen Huatan Decoction combined with letrozole on FSH and LH in patients with polycystic ovary syndrome. Methods: From February 2015 to March 2017,a total of 90 cases of polycystic ovary syndrome diagnosed by infertility department in our hospital were divided into the observation group and the control group,with 45 cases in each group. All patients were treated with letrozole starting from menstruation 5 D. The observation group was treated with Bushen Huatan Decoction on the basis of the control group. We observed the two groups endometrial thickness and ovarian volume of acne symptoms and the menstrual dysfunction of patients,and calculated the ovulation rate and pregnancy rate. The follicle stimulating hormone,luteinizing hormone estradiol,testosterone and prolactin level were measured. Results: The ovarian volume,acne score and menstrual disorder score in the observation group were significantly lower than those in the control group( P < 0. 05). There was no significant difference in endometrial thickness between the observation group and the control group. The ovulation rate of the observation group was significantly higher than that of the control group( P < 0. 05). The pregnancy rate was slightly higher than that of the control group,but there was no statistical difference( P > 0. 05). After treatment,the levels of follicle stimulating hormone( FSH),luteinizing hormone( LH),estradiol( E2),testosterone( T) and prolactin( PRL) in the observation group were significantly lower( P < 0. 05). After treatment,the level of reproductive hormones in the observation group was significantly lower than that in the control group and the difference between the two groups was statistically significant( P < 0. 05). Conclusion: Tonifying kidney and resolving phlegm combined with letrozole can effectively promote ovulation in patients with polycystic ovary syndrome and improve the levels of reproductive hormones such as FSH and LH.
作者
霍梦逸
侍方
加媛
HUO Mengyi;SHI Fang(Beijing Jishuitan Hospital,Beijing 100096,China;Xuanwu Hospital of TCM,Beijing 100050,China)
出处
《辽宁中医杂志》
CAS
2019年第4期732-735,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
多囊卵巢综合征
补肾化痰方
排卵
生殖激素
polycystic ovary syndrome
Bushen Huatan Decoction
ovulation
reproductive hormones
