摘要
背景衰弱作为机体脆弱的综合表现,是衰老的主要问题。睡眠障碍影响着50%的老年人,且随着年龄的增加其影响越严重。但目前衰弱与睡眠问题的关系尚不明确。目的在中国老年人群中探索衰弱与睡眠障碍的关联,以期为老年人衰弱干预提供理论依据。方法本研究于2016年4—6月选取如皋长寿和衰老研究中1 792例老年人的睡眠和衰弱数据。收集老年人基线资料、睡眠情况〔采用匹兹堡睡眠质量指数(PSQI)量表评价,以PSQI量表得分>10分为有睡眠障碍,≤10分为睡眠正常〕、衰弱情况〔采用实验室衰弱指数(FI-LAB)评价,以FI-LAB<0.1为非衰弱,0.1～0.2为轻微衰弱,>0.2～0.3为轻度衰弱,>0.3～0.4为中度衰弱,>0.4为重度衰弱〕。结果不同性别老年人BMI、职业、婚姻状况、文化程度、吸烟情况、饮酒情况、自报健康情况、PSQI量表得分、睡眠情况比较,差异有统计学意义(P<0.05)。不同睡眠情况老年人性别、吸烟情况、自报健康情况、衰弱情况比较,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,当调整了年龄、职业、婚姻状况、文化程度、吸烟情况、饮酒情况、自报健康情况时,女性老年人FI-LAB与睡眠情况有关联〔OR=1.238,95%CI(1.020,1.503),P<0.05〕,男性老年人FI-LAB与睡眠情况有关联〔OR=0.621,95%CI(0.432,0.894),P<0.05〕,女性老年人重度衰弱与睡眠情况有关联〔OR=3.755,95%CI(1.188,11.868),P<0.05〕,男性老年人衰弱情况与睡眠情况无关联〔OR=0.291,95%CI(0.030,2.836),P>0.05〕。结论女性老年人衰弱与睡眠障碍有关联,睡眠障碍高风险女性老年人衰弱的可能性较大。
Background Frailty,as a comprehensive manifestation of the increased vulnerability of body,is the main problem of aging.Sleep disturbances affects 50%of the elderly,and its effects increase with age.However,the association between frailty and sleep problems is still unclear.Objective To explore the association between frailty and sleep disturbances in the elderly in China,providing a theoretical basis for the delivery of frailty interventions in this population.Methods Sleep or frailty data of 1 792 elderly people in the Rugao longevity and aging study,were collected during the period from April to June 2016.Baseline data,sleep status〔evaluated by Pittsburgh Sleep Quality Index(PSQI)scale,with score>10 was defined as sleep disturbances,≤10 as normal〕,and frailty〔evaluated by Laboratory Frailty Index(FI-LAB),FILAB<0.1 as non-frailty,0.1-0.2 as slight frailty,>0.2-0.3 as mild frailty,>0.3-0.4 as moderate frailty,and>0.4 as severe frailty〕were also collected.Results Significant gender-related differences were found in terms of BMI,occupation,marital status,education level,smoking,drinking,self-reported health,PSQI scale score and sleep status(P<0.05).There were significant differences in gender,smoking,self-reported health status and frailty of the elderly with different sleep status(P<0.05).Logistic regression analysis showed that FI-LAB was associated with sleep status in both females〔OR=1.238,95%CI(1.020,1.503),P<0.05〕and males〔OR=0.621,95%CI(0.432,0.894),P<0.05〕,the association between severe frailty and sleep status was significant in females〔OR=3.755,95%CI(1.188,11.868),P<0.05〕,while the same association was not found in males〔OR=0.291,95%CI(0.030,2.836),P>0.05〕,after adjusting for age,occupation,marital status,education level,smoking,drinking,and self-reported health.Conclusion Sleep disturbances is associated with increased risk of frailty in el derly females.
作者
王宇宸
马腾
蒋晓燕
李淑娟
王笑峰
WANG Yuchen;MA Teng;JIANG Xiaoyan;LIShujuan;WANG Xiaofeng(School of Life Sciences,Hehai University,Shanghai 200433,China;Department of Pathology and Pathophysiology,Tongji University School of Medicine,Shanghai 200092,China;Department of Neurology,Beijing Chao-yang Hospital,Capital Medical University,Beijing 100020,China)
出处
《中国全科医学》
CAS
北大核心
2019年第15期1766-1771,共6页
Chinese General Practice
基金
国家自然科学基金资助项目(81571372
81670465
81600577)
