摘要
该研究利用大孔吸附树脂D101、MCI树脂、正相硅胶、ODS、Sephadex LH-20和反相HPLC等多种色谱分离方法,对红根草95%乙醇提取物的乙酸乙酯萃取部位进行了分离。结果表明:通过分离共得到了10个化合物,经波谱数据分析鉴定为3-表-白桦脂酸(1)、白桦脂醇(2)、齐墩果酸(3)、3β,6β,23-三羟基-12-烯-28-齐墩果酸(4)、高根二醇(5)、2α,3β,23-三羟基-12-烯-28-乌苏酸(6)、2α,3β,19α-三羟基-12-烯-28-乌苏酸(7)、2α,3α,24-三羟基-12-烯-28-乌苏酸(8)、2α,3α,24-三羟基-12,20(30)-二烯-28-乌苏酸(9)、山奈酚-3-O-葡萄糖苷(10)。其中,化合物1为首次从鼠尾草属植物中分离得到,化合物2、4、5、6、7、8、9、10为首次从该植物中分离得到。
From a 95% ethanol extract of Salvia prionitis , ten compounds were isolated by means of various chromatographic techniques including column chromatography over macroporous resin D101, MCI gel, silica gel, ODS, Sephadex LH-20, and reversed-phase HPLC. Their structures were elucidated using spectroscopic data as 3-epi-betulinic acid( 1 ), betulin( 2 ), oleanic acid( 3 ), 3 β, 6 β, 23-trihydroxyolean-12-en-28-oic acid( 4 ), erythrodiol( 5 ), 2 α, 3 β, 23-trihydroxyurs-12-en-28-oic acid( 6 ), 2 α, 3 β, 19 α-trihydroxyurs-12-en-28-oic acid( 7 ), 2 α, 3 α, 24-trihydroxyurs-12-en-28-oic acid( 8 ), 2 α, 3 α, 24-trihydroxyurs-12, 20(30)-dien-28-oic acid( 9 ), and kaempferol-3- O -glucoside( 10 ). Compound 1 was obtained from the genus of Salvia for the first time, and compounds 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 were obtained from this plant for the first time.
作者
霍华珍
陈绍农
Guido F.PAULI
蒋小华
刘章彬
李典鹏
于洋
HUO Huazhen;CHEN Shaonong;JIANG Xiaohua;LIU Zhangbin;LI Dianpeng;YU Yang(College of Life Sciences, Guangxi Normal University , Guilin 541006, Guangxi, China;Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences , Guilin 541006, Guangxi, China;Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago 60612, IL, USA)
出处
《广西植物》
CAS
CSCD
北大核心
2019年第4期516-522,共7页
Guihaia
基金
广西壮族自治区"八桂学者"专项项目
中国科学院"西部之光"基金(人字[2018]6号)
广西科学院基本科研业务费项目(2017YJJ23006)
广西师范大学-广西壮族自治区中国科学院广西植物研究所研究生联合培养基地示范建设项目~~
关键词
红根草
化学成分
提取分离
结构鉴定
三萜
Salvia prionitis
chemical constituents
extraction and isolation
structure identification
triterpenoids
