摘要
目的总结分析下肢深静脉血栓患者的发病危险因素。方法选择2016年1月～2018年1月南京鼓楼医院收治的368例深静脉血栓患者作为病例组,同期体检中心接受体检人员462例作为对照组,对两组年龄、性别、是否合并心血管疾病、是否合并糖尿病、有无创伤/骨折史、有无手术史或长期制动、有无恶性肿瘤史、有无妊娠或产后等观察指标进行单因素分析,将单因素分析筛选出的有意义因素纳入Logistic回归方程进行多因素分析。结果单因素分析显示静脉血栓与患者年龄、是否合并心血管疾病、有无创伤/骨折史、有无手术史或长期制动、有无恶性肿瘤史相关(P<0.05);而与性别、是否合并糖尿病、有无妊娠/产后无相关性(P>0.05)。但是临床认为糖尿病和妊娠/产后也是DVT发生的可能因素,因此将二者与其他相关因素共同纳入Logistic分析,显示年龄≥40岁、创伤或骨折、手术与制动、恶性肿瘤、妊娠或产后是下肢深静脉血栓的主要危险因素(P<0.05)。结论下肢深静脉血栓的致病因素以获得性因素为主,辨识危险因素并尽早采取预防措施可降低深静脉血栓的发病率,降低肺动脉栓塞的发生,降低病死率。
Objective To analyze the clinical risk factors of deep venous thrombosis of lower extremity. Methods A total of 368 patients with deep vein thrombosis admitted to Nanjing Gulou Hospital from January 2016 to January 2018 were selected as the case group. 462 healthy volunteers who participated in the physical examination at the same time were selected as the control group. Univariate anlysis was conducted in both groups on age, gender, presence or absence of cardiovascular disease, presence or absence of diabetes, presence or absence of history of trauma/fracture, presence or absence of history of surgery or long-term restriction of movement, presence or absence of history of malignancy, presence or absence of pregnancy or postpartum period. The meaningful factors selected by univariate analysis were includeed in the logistic regression equation for multivariate analysis. Results Univariate analysis showed that venous thrombosis was associated with age, cardiovascular disease, trauma/fracture history, history of surgery or long-term restriction of movement, and history of malignancy(P<0.05), but not with diabetes, pregnancy or postpartum period(P>0.05). However, it was considered that diabetes and pregnancy/postpartum period were also possible factors for the occurrence of DVT. Therefore, these two factors were also included in the logistic analysis together with other related factors, showing that age ≥40 years, trauma or fracture, surgery or long-term restriction of movement, malignancy, pregnancy or postpartum period were main risk factors of deep venous thrombosis of lower extremity(P<0.05). Conclusion The pathogenic factors of deep venous thrombosis of lower extremities are mainly acquired factors, and identifying risk factors and taking preventive measures as soon as possible can reduce the incidence of deep vein thrombosis, reduce the incidence of pulmonary embolism, and reduce the mortality rate.
作者
许婉婷
王宝彦
方芸
XU Wanting;WANG Baoyan;FANG Yun(Drum Tower Clinical College of Integrative Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Pharmacy, Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《中国现代医生》
2019年第5期9-12,15,共5页
China Modern Doctor
关键词
深静脉血栓
危险因素
预防措施
Deep vein thrombosis
Risk factors
Analysis
Preventive measures
