摘要
目的探讨中性粒细胞/淋巴细胞比值(NLR)、红细胞分布宽度(RDW)与慢性阻塞性肺疾病(CDPD)合并肺动脉高压(PH)的相关性。方法回顾性分析2015年7月至2018年8月期间入住安徽省第二人民医院呼吸内科的97例COPD患者临床资料。根据超声心动图诊断结果,分为肺动脉压正常组(PASP<40mmHg,n=49)和肺动脉高压组(PASP≥40mmHg,n=48)。两组基线资料及临床指标(WBC、NLR、RDW、CRP、PaCO_2、氧合指数)进行比较,Pearson相关性分析明确NLR、RDW与肺动脉收缩压(PASP)的相关性。结果较肺动脉压正常组相比,肺动脉高压组NLR、RDW和PaCO_2水平偏高,氧合指数偏低,差异均具有统计学意义(P<0.05),两组WBC、CRP水平相似,差异无统计学意义(P>0.05)。NLR、RDW和PaCO_2均与PASP呈正相关(P<0.05),氧合指数与PASP呈负相关(P<0.001)。NLR与CRP呈正相关(P<0.001),RDW与氧合指数呈负相关(P=0.001)。结论 NLR和RDW水平均与COPD患者肺动脉压力呈明显相关。二者可作为反映COPD合并肺动脉高压病情的有价值指标。
Objective To explore the relationship between neutrophil/lymphocyte ratio(NLR),red blood cell distribution(RDW)width and pulmonary hypertension(PH)induced by chronic obstructive pulmonary disease.Methods The clinical data of patients with COPD from July 2015 to August 2018 were retrospectively analyzed.According to the detection results of cardiac ultrasonography,97 patients were divided into the normal pulmonary artery pressure group(PASP<40mmHg,n=49)and the pulmonary hypertension group(PASP≥40mmHg,n=48).General condition and clinical data(WBC,NLR,RDW,CRP,PaCO2,oxygenation index)were compared between the two groups.Relations between NLR,RDW and pulmonary arterial systolic pressure(PASP)were investigated by Pearson correlation analysis.Results Compared to the data of the normal pulmonary artery pressure group,NLR,RDW and PaCO2 of the pulmonary hypertension group were higher,while oxygenation index were lower(P<0.05).However,the levels of WBC and CRP had no statistical difference between the two groups(P>0.05).Any one of NLR,RDW and PaCO2 had positively significant correlation with PASP(P<0.05),while oxygenation index was negatively correlated with PASP(P<0.001).NLR was positively correlated with CRP(P<0.001),while RDW was negatively with oxygenation index(P=0.001).Conclusion Both of the levels of NLR and RDW were significantly correlated to PASP of COPD patients.NLR and RDW may be used as useful indexes to reflect the severity of pulmonary hypertension induced by chronic obstructive pulmonary disease.
作者
张鹏
齐保龙
孙耕耘
ZHANG Peng;QI Bao-long;SUN Geng-yun(Department of Respiratory Medicine,the Second People's Hospital of Anhui,Hefei 230000,China)
出处
《临床肺科杂志》
2019年第4期650-654,共5页
Journal of Clinical Pulmonary Medicine
关键词
中性粒细胞/淋巴细胞比值
红细胞分布宽度
肺动脉高压
neutrophil/lymphocyte ratio(NLR)
red blood cell distribution width(RDW)
pulmonary hypertension(PH)
