摘要
口腔种植体相关感染已成为影响种植体成功率的重要因素。近年来,研究开发具有抗菌性能的种植体表面涂层材料,尤其是载药涂层材料,已成为新的研究热点。共价接枝是将抗菌药物通过共价键固定于种植体表面的新型载药方法。与其他载药方法相比,其具有优化药物释放模式、改变药物的抗菌机制、提高药物稳定性等优点。本文就共价接枝构建钛种植体载药抗菌涂层的构建方式、应用优劣势及发展前景进行综述。
Implant-related infection has become an important factor affecting the success rate of titanium implants and a new research hotspot in developing coating materials with antibacterial properties on the implant surface, especially drugloaded antibacterial coatings. Covalent grafting is an emerging strategy for the immobilisation of antibacterial drugs on the implant surface through covalent bonds. Compared with other drug-loading strategies, covalent grafting is advantageous in optimising drug release kinetics, novel antibacterial mechanisms and drug stability. This article reviewed the modes of construction, application advantages/disadvantages and prospective development of drug-loaded antibacterial coatings of titanium implants based on covalent grafting.
作者
刘育豪
袁泉
张士文
Liu Yuhao;Yuan Quan;Zhang Shiwen(State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)
出处
《国际口腔医学杂志》
CAS
CSCD
2019年第2期228-233,共6页
International Journal of Stomatology
基金
国家自然科学基金(81571001)~~
关键词
钛种植体
载药
抗菌
共价接枝
titanium implant
drug-loading
antibacterial
covalent grafting
