摘要
目的:研究酸性核酸蛋白32A(acidic leucine-rich nuclear phosphoprotein,ANP32A)在结直肠癌肝转移中的临床意义。方法:应用免疫组织化学法检测156例结直肠癌组织(其中59例患者存在肝转移)中癌与癌旁组织的表达水平,并探讨其表达水平与结直肠癌肝转移的相关性。结果:ANP32A蛋白在结直肠癌组织中的阳性表达率为59.6%(93/156),癌旁组织的阳性表达率为19.9%(31/156),差异具有统计学意义(P<0.05)。ANP32A在肝转移患者中的阳性表达率7 9.7%(47/59),明显高于无肝转移患者中的阳性表达率4 7.4%(46/97),差异具有统计学意义(P<0.05)。单因素分析结果显示肿瘤的分化程度、淋巴结转移以及ANP32A的表达与肝转移相关(均P<0.05)。多因素logistic回归分析结果提示肿瘤分化程度及ANP32A蛋白阳性表达是结直肠癌肝转移的独立危险因素(均P<0.05)。结论:ANP32A在结直肠癌中的高表达与结直肠癌肝转移相关,可望成为结直肠癌肝转移治疗的潜在靶点。
Objective: To investigate the expression of ANP32A in colorectal cancer with liver metastasis. Methods: Immunohistochemistry was used to analyze the expressions of ANP32A in 156 colorectal cancer specimens and matched paratumorous normal specimens (59 patients with liver metastasis). The correlation of ANP32A expression level with colorectal cancer liver metastasis was carried out. Results: The higher expression of ANP32A were found in colorectal specimens compared with matched paratumorous normal specimens (P<0.05), the positive rates were 59.6% and 19.9%, respectively. Expression of ANP32A in patients with liver metastasis was significantly higher than that in patients without liver metastasis (79.7% vs 47.4%). Single factor analysis showed that liver metastasis was associated with histological differentiation, lymph node metastasis, and the expression of ANP32A (all P<0.05). Multivariate logistic regression analysis further showed that histological differentiation and higher expression of ANP32A were independent risk factor in colorectal cancer with liver metastasis. Conclusion: The overexpression of ANP32A is associated with carcinogenesis and liver metastasis of CRC, which suggests that the positive expression of ANP32A may be the potential target in CRC with liver metastasis.
作者
杨光华
刘春玲
吕春秀
虞向阳
崔明新
张国志
YANG Guanghua;LIU Chunling;Lü Chunxiu;YU Xiangyang;CUI Mingxin;ZHANG Guozhi(Department of General Surgery, North China University of Science and Technology Affiliated Hospital, Tangshan Hebei 063000;Department of Pathology, Tangshan People’s Hospital, Tangshan Hebei 063000;Department of Hematopathology, North China University of Science and Technology Affiliated Hospital, Tangshan Hebei 063000, China)
出处
《临床与病理杂志》
2018年第12期2566-2569,共4页
Journal of Clinical and Pathological Research
关键词
结直肠癌
肝转移
临床病理参数
酸性核酸蛋白32A
colorectal cancer
liver metastasis
clinicopathological features
acidic leucine-rich nuclear phosphoprotein
