摘要
目的:探讨早发型子痫前期(EOPE)孕妇血清胎盘生长因子(PLGF)与子宫动脉血流参数、分娩孕周及新生儿出生体重的相关性。方法:选取本院EOPE孕妇作为观察组,同期血压正常的孕妇作为对照组,比较两组孕妇血清PLGF与子宫动脉血流参数的差异,分析观察组孕妇血清PLGF水平与子宫动脉血流及分娩孕周、新生儿出生体重的关系。结果:观察组孕妇分娩孕周、新生儿出生体重及血清PLGF水平低于对照组(P<0.001),子宫动脉血流S/D、RI及PI值均明显高于对照组(P<0.05);观察组血清PLGF水平与子宫动脉血流S/D、RI及PI值均呈负相关(r=-0.832、-0.366、-0.562,P<0.001),与分娩孕周及新生儿出生体重均呈正相关(r=0.327、0.763,P<0.005)。结论:EOPE孕妇血清PLGF水平与EOPE发生发展密切相关,可以作为预测EOPE临床诊断的参考指标。
Objective:To explore the correlation between the placental growth factor(PLGF)level and uterine arterial blood flow,gestational weeks,or newborn weight of pregnant women with early onset preeclampsia(EOPE).Methods:The pregnant women with EOPE were selected into study group,and normal pregnant women were selected into control group during the same time.The differences of serum PLGF level and uterine artery blood flow parameters were compared between the two groups.The relationship between the level of serum PLGF and uterine artery blood flow,the gestational weeks,or the newborn weight of women in study group was also analyzed.Results:The delivery gestational weeks,newborn birth weight and the level of serum PLGF of women in study group were significant lower than those of women in control group(P<0.001),but the S/D,RI and PI of uterine artery blood flow of women in study group were significant higher than that those of women in control group(P<0.05).In the study group,the level of serum PLGF was negatively correlated to the S/D,RI and PI values of uterine artery blood flow(r=0.832,0.366,0.562,P<0.001),but was positively correlated to the gestational weeks and the newborn weight(r=0.327,0.763,P<0.005).Conclusion:The level of serum PLGF of pregnant women is closely related to the occurrence of EOPE,which can be used as a reference indicator for predicting EOPE.
作者
周美芳
ZHOU Meifang(Wenzhou City Integrated Hospital of Traditional Chinese Medicine and Western Medicine,Zhejiang Province,325000)
出处
《中国计划生育学杂志》
2019年第1期107-110,共4页
Chinese Journal of Family Planning
