摘要
目的探讨血清C反应蛋白(CRP)和肿瘤标志物[癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原(CA)125、CA19-9]检测对消化道恶性肿瘤的诊断价值。方法选取该院2017年1月至2018年6月收治的消化道恶性肿瘤患者120例作为恶性组,消化道良性疾病患者100例作为良性组,同时选取同期于该院体检的健康者50例作为对照组。检测患者入院及治疗后,健康体检者入院时的血清CRP和肿瘤标志物水平,对比上述指标的变化。结果入院时恶性组各项血清肿瘤标志物水平均高于良性组和对照组,恶性组和良性组血清CRP水平显著高于对照组,且良性组高于恶性组,差异均有统计学意义(P<0.05)。经过治疗后,血清CRP和各肿瘤标志物阳性率均明显下降,差异有统计学意义(P<0.05)。随访35例复发患者,血清CRP和肿瘤标志物水平明显升高,差异有统计学意义(P<0.05)。结论血清CRP在早期消化道良恶性疾病中的鉴别诊断价值不大,在消化道恶性肿瘤的筛查中血清CRP和各肿瘤标志物单项检测与联合检测阳性率差别不大,仅在某些项目上略有提高。但是CRP在术后肿瘤复发时明显升高,可以作为治疗后的动态观察指标,在术后肿瘤复发中起到预警作用。
Objective To explore the value of detection of serum CRP and tumor markers CEA,AFP,CA125 and CA19-9 in digestive tract malignant tumors.Methods One hundred and twenty cases of digestive tract malignant tumor in the hospital from January 2017 to June 2018 were selected as the malignant group,100 patients with gastrointestinal benign diseases served as the benign group,at the same time,50 persons undergoing physical examination in the hospital were selected as the control group.The levels of serum CRP and tumor markers(CEA,AFP,CA125,CA19-9)were detected in the patients at admission and after treatment and healthy control at admission,and the changes of above indicators were compared among the groups.Results The levels of serum tumor markers in the malignant group were higher than those in the benign group and the control group,the serum CRP level in the malignant group was significantly higher than that in the control group,moreover the benign group was higher than the malignant group,the differences were statistically significant(P<0.05).The positive rates of serum CRP and tumor markers after treatment were significantly decreased,and the difference was statistically significant(P<0.05).During follow up period in 35 cases of tumor recurrence,the serum CRP and tumor markers levels were significantly increased,and the difference was statistically significant(P<0.05).Conclusion Serum CRP has little value in differential diagnosis of benign and malignant diseases in early digestive tract.The positive rate of serum CRP and individual and combined detection of various tumor markers for screening digestive tract tumors have little difference and is slightly improved in some items.However CRP is significantly increased in postoperative tumor recurrence and can serve as the dynamic observation index after treatment,which plays an early warning role in postoperative tumor recurrence.
作者
刘淼
顾春瑜
王海滨
LIU Miao;GU Chunyu;WANG Haibin(Department of Clinical Laboratory,First Affiliated Hospital,General Hospital of PLA,Beijing 100037,China)
出处
《检验医学与临床》
CAS
2019年第4期493-495,498,共4页
Laboratory Medicine and Clinic
