摘要
背景:磁共振弥散张量成像技术是一项新兴的磁共振成像方法,由于其利用水分子在组织中自由扩散的原理揭示组织病变特点,常被用于检测神经系统细微结构的改变以及评价神经系统疾病的预后。目的:综述磁共振弥散张量成像技术的特征及临床应用的作用。方法:第一作者以"弥散张量成像、各向异性参数、表观弥散系数、纤维示踪、白质、脑血管、脊髓、肌肉、椎间盘"为中文检索词,以"diffusion tensor imaging,DTI,FA,ADC,fibre tracing,DTT,white matter,cerebrovasculardiseases,spinalcord,muscle,intervertebraldisc"为英文检索词,检索中国期刊全文数据库、ELSEVIER数据库、EMBASE数据库、Springer数据库、IEEE、Wiley Online Library、Google Scholar和PubMed数据库中关于磁共振弥散张量成像技术的研究与应用的文章,共纳入41篇文献。结果与结论:弥散张量成像技术是一项尚待继续开发的功能性磁共振成像技术,通过计算组织内水分子自由扩散特征参数值,反映其扩散能力,继而能较准确地显示组织内部微观结构的表现,目前弥散张量成像技术应用的领域较为广泛,比如脊髓病变,阿尔茨海默病、癫痫及脑肿瘤等中枢神经系统疾病,周围神经损伤,脑梗死等脑血管疾病,椎间盘退变,肌肉系统病变等方面,但技术开发程度还有很大空间,未来弥散张量成像技术在肌肉纤维示踪、组织损伤评估等方面的研究尚有很大前景,有望成为颈椎病、腰椎间盘突出症等退行性疾病的无创性评价肌肉损伤的间接特征性的重要技术指标,从而为临床早期诊断和治疗肌肉结构改变提供有力的帮助。
BACKGROUND: Diffusion tensor imaging is a new method of magnetic resonance. Because it utilizes the principle of free diffusion of water molecules in tissues to reveal the characteristics of tissue lesions, it is often used to detect changes in the subtle structure of the nervous system and to evaluate the prognosis of neurological diseases. OBJECTIVE: To review the characteristics and clinical application of magnetic resonance diffusion tensor imaging. METHODS: The keywords were “diffusion tensor imaging, DTI, FA, ADC, fiber tracing, DTT, white matter, cerebral vascular, spinal cord, muscle, intervertebral disc” in Chinese and English, respectively. Articles relevant about the research and application of magnetic resonance diffusion tensor imaging were search in CNKI, ELSEVIER, EMBASE, Springer, IEEE, Wiley Online Library, Google Scholar and PubMed Databases. Totally 41 eligible articles were included. RESULTS AND CONCLUSION: Diffusion tensor imaging is a functional magnetic resonance imaging technique, which should be developed. By calculating the characteristic parameters of free diffusion of water molecules in the tissue, it can reflect the diffusion ability, and then it is able to show the microstructure of the tissue accurately. Diffusion tensor imaging technology is widely used in a wide range of areas, for example, spinal cord diseases, Alzheimer’s disease, epilepsy, brain tumors and other central nervous system diseases, peripheral nerve injury, cerebral infarction and other cerebrovascular diseases, intervertebral disc degeneration, and muscular system diseases. However, there is still a lot of space for technical development, and diffusion tensor imaging technology in the future in the tracing of muscle fibers, tissue damage assessment and other aspects still has great prospects. It is expected to become an important technical indicator in noninvasive evaluation of the indirect characteristics of muscle injury in degenerative diseases, such as, cervical spondylosis and lumbar disc herniation, so as to provide a powerful help for early clinical diagnosis and treatment of muscle structural changes.
作者
刘建航
刘昊
陈道云
徐志为
谢桂鑫
李锦威
Liu Jianhang;Liu Hao;Chen Daoyun;Xu Zhiwei;Xie Guixin;Li Jinwei(Department of Orthopedic Manipulation, Ruikang HospitalAffiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China;Department ofOrthopedics, Linwu County Hospital of Traditional Chinese Medicine, Chenzhou 424300, Hunan Province, China;Yown Kang Tong ChineseMedical Centre, Hong Kong Special Administrative Region 999077, China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第8期1241-1247,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金(81760796)
项目负责人:陈跃平
广西科学研究与技术开发计划课题(桂科攻1598012-34)
项目负责人:刘建航
广西医疗卫生适宜技术开发与推广应用项目(S2017054)
项目负责人:刘建航
广西青年智库研究会(GXQNZKA-1702)
项目负责人:刘建航~~
