摘要
针对医院获得性感染细菌耐药性的问题,在细菌纤维素(BC)表面接枝卟啉制备了一种光敏抗菌材料。首先将二醛细菌纤维素浸渍在高碘酸钠(NaIO_4)中制备得到二醛细菌纤维素(BC-CHO),然后利用还原胺化反应在BC-CHO表面接枝乙二胺(EDA),最后共价接枝活化的原卟啉(PpIX)合成得到乙二胺化细菌纤维素原卟啉纤维膜。借助傅里叶变换红外光谱仪、热重分析仪、X射线衍射仪、扫描电子显微镜对纤维膜的性能进行分析。结果表明:二醛细菌纤维素表面成功地接枝了氨基间隔臂乙二胺和PpIX;随着NaIO_4浓度的提高,BC-CHO醛基含量逐渐提高,热分解温度逐渐降低,晶体结构逐渐发生转变;纤维膜对金黄色葡萄球菌的初次抗菌率可达到98%,经过5次酒精洗涤后仍然具有良好的抑菌性能。
In view of the drug-resistant characteristic of nosocomial bacterial infection,a novel photosensitive antibacterial material prepared by grafting porphyrin were synthesized.Oxidized bacterial cellulose(BC-CHO)was prepared by immersing in sodium periodate(NaIO 4)firstly,then ethylenediamine(EDA)was grafted onto the bacterial cellulose by reductive amination reaction,and finally protoporphyrin IX(PpIX)grafted ethylenediamined bacterial cellulose fibrous membrane was obtained by covalenting activated PpIX onto as-obtained ethylenediamined bacteria cellulose.Fourier transform infrared spectrometry,thermogravimetric analysis,X-ray diffraction and scanning electron microscopy were utilized to analyze the functional groups,thermal properties,crystal structure of as-grafted fibrous membranes.At last,antibacterial behavior of BC-EDA-PpIX fibrous membrane and its reusability were discussed.The results show that amino spacer arm as well as the PpIX is successfully grafted onto the dialdehyde bacterial cellulose.Furthermore,the aldehyde content of BC-CHO gradually increases with the increase of NaIO 4 concentration.Meanwhile,the thermal decomposition temperature decreases gradually,and the crystallinity slightly decreases.The first-time antibacterial effect of the as-synthesized BC-EDA-PpIX fibrous membrane against Staphylococcus aureus reaches 98%,and such material still shows good antibacterial activity even after 5 times of ethanol washing.
作者
董建成
葛孝栋
王清清
魏取福
DONG Jiancheng;GE Xiaodong;WANG Qingqing;WEI Qufu(Key Laboratory of Eco-Textiles(Jiangnan University),Ministry of Education,Wuxi,Jiangsu 214122,China)
出处
《纺织学报》
EI
CAS
CSCD
北大核心
2018年第11期20-26,共7页
Journal of Textile Research
基金
2018年江苏省研究生科研创新计划(KYCX18_1835)
国家自然科学基金青年科学基金资助项目(51603090)
中央高校科研专项基金资助项目(JUSRP115A04)
江苏高校优势学科建设工程资助项目(苏政办发[2014]37号)
关键词
光敏抗菌材料
细菌纤维素
原卟啉
抗菌性能
photodynamic antibacterial material
bacterial cellulose
protoporphyrin IX
antibacterial property
