摘要
烟酰胺腺嘌呤二核苷酸（NAD+）是生物化学反应的重要介质，作为辅酶参与氧化还原反应，也可以作为底物参与分子信号传递。NAD+在细胞内合成与消耗之间的动态平衡将直接影响新陈代谢、生物昼夜节律以及衰老等多种生物学过程。NAD+失衡在中枢神经元变性过程中起关键作用，而视网膜属于中枢神经系统的延伸。近年的研究也证实了NAD+失衡参与视网膜变性。NAD+失衡偶联视网膜神经变性的机制较为复杂，可能涉及线粒体结构功能损伤、聚ADP核糖聚合酶（PARP）过度激活、sirtuins家族功能异常等。分析NAD+失衡与视网膜神经变性的关系有助于进一步阐明视网膜神经变性的分子机制，为视网膜神经变性相关疾病治疗提供新的思路。本文主要针对NAD+代谢参与视网膜神经元变性的研究进展进行综述。
Nicotinamide adenine dinucleotide(NAD+)is a critical mediator in biochemical reactions.It serves both as a coenzyme in reduction-oxidation reactions,and as a cosubstrate for other enzymes in molecular signal transduction.The homeostasis of intracellular synthesis and consumption of NAD+can directly affect a variety of biological processes,such as metabolism,circadian entrainment and aging.It is demonstrated that NAD+imbalance plays a key role in central neuronal death and axonal degeneration,and the retina is an extension of the central nervous system.In recent years,the effect of NAD+imbalance on retinal neurodegeneration has been confirmed.The mechanism of NAD+imbalance coupling retinal neurodegeneration is complex,which may involve mitochondrial destruction or dysfunction,poly(ADP-ribose)polymerase(PARP)over-activation,and sirtuins family function abnormalities.Analysis of the relationship between NAD+imbalance and retinal neurodegeneration can help to further elucidate the molecular mechanism of retinal neurodegeneration and provide new ideas for the treatment of retinal neurodegenerative diseases.This review summarized current opinions on the relationship between NAD+metabolism and retinal neurodegeneration.
作者
刘洋(综述)
罗学廷(审校)
Liu Yang;Luo Xueting(Department of Ophthalmology,Shanghai First People's Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai 200080,China;Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai 200080,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2018年第10期808-811,共4页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金项目（81700828）；“上海高校青年东方学者”人才计划项目（QD2016003）；上海市科学技术委员会科研项目（16140900800、16dz2251500）
