摘要
目的分析脑血管疾病所致认知障碍应用尼莫地平治疗的临床效果。方法选取2014年6月~2017年6月我院收治的100例脑血管疾病所致认知障碍患者作为研究对象,按照随机数字表法将患者分为两组,每组各50例。对照组患者给予常规治疗,研究组患者在此基础上加用尼莫地平治疗。观察比较两组患者治疗前后的简易精神状态量表(MMSE)、日常生活活动能力量表(ADL)评分、临床治疗效果及不良反应发生情况。结果治疗前,研究组的MMSE、ADL评分与对照组比较,差异无统计学意义(P>0.05)。治疗后,研究组患者的MMSE评分为(25.6±2.6)分,显著高于对照组的(21.3±1.9)分,研究组患者的ADL评分为(27.8±3.5)分,低于对照组的(38.2±4.1)分,差异均有统计学意义(P<0.05)。研究组患者的治疗总有效率为96.0%,显著高于对照组的80.0%,差异有统计学意义(P<0.05)。研究组患者的不良反应发生率为4.0%,低于对照组的18.0%,差异有统计学意义(P<0.05)。结论对脑血管疾病所致认知障碍患者应用尼莫地平治疗,可有效缓解患者症状,改善患者生活质量,提高临床效果,且安全性高,可推广应用。
Objective To analyze the clinical effect of Nimodipine in the treatment of cognitive impairment caused by cerebrovascular diseases.Methods A total of 100 patients with cognitive impairment caused by cerebrovascular diseases who were admitted into our hospital from June 2014 to June 2017 were selected as subjects.They were evenly divided into two groups by the random number table method,50 cases in each group.In control group,routine treatment was used,while in the research group,Nimodipine was added on this basis.The simple mental state scale(MMSE)score,the daily activity ability scale(ADL)score before and after treatment,the clinical treatment effect and adverse reactions of the two groups were observed and compared.Results Before treatment,the MMSE and ADL scores of the research group were compared with the control group,and the differences were not statistically significant(P>0.05).After treatment,the MMSE score of patients in the research group was(25.6±2.6)points,which was significantly higher than that of the control group of(21.3±1.9)points,the ADL score of patients in the research group was(27.8±3.5)points,which was lower than that in the control group of(38.2±4.1)points,and the differences were statistically significant(P<0.05).The total effective rate of patients in the research group was 96.0%,which was significantly higher than 80.0%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the research group was 4.0%,which was less than 18.0%in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of Nimodipine in patients with cognitive impairment caused by cerebrovascular diseases can effectively alleviate patients′symptoms,ameliorate the quality of life,and improve the clinical effect in high safety,which can be promoted.
作者
丘海峰
QIU Hai-feng(Department of Internal Medicine,the Traditional Chinese Medicine Hospital in Dapu County of Meizhou City,Guangdong Province,Dapu 514200,China)
出处
《中国当代医药》
2018年第8期135-138,共4页
China Modern Medicine
关键词
脑血管疾病
尼莫地平
认知障碍
临床效果
生活质量
Cerebrovascular disease
Nimodipine
Cognitive impairment
Clinical effect
Quality of life
