摘要
目的研究宫颈癌筛查系统初善仪(TS)与宫颈刮片细胞学及液基薄层细胞学检测(TCT)在宫颈癌筛查中的临床应用。方法将398例宫颈病变患者随机分为2组,第1组198例,依次进行TS和宫颈刮片检查,第2组200例,依次进行TS和TCT,对入组患者行电子阴道镜检查及宫颈活检,据病理结果对三种筛查方法的敏感度、特异度做临床对比。结果第1组:TS、宫颈刮片阳性分别为42例和36例,病理学检查阳性为41例。敏感度分别为87.80%、65.85%,特异度为96.18%、94.28%,TS敏感性高于宫颈刮片和TCT(P<0.05),特异度差异无统计学意义(P>0.05)。第2组TS、TCT阳性分别为52例和40例,病理学检查阳性为48例。敏感度分别为87.50%、70.83%,特异度为93.43%、96.05%。TS敏感度优于宫颈刮片和TCT,差异有统计学意义(P<0.05),特异度TS与宫颈刮片和TCT差异无统计学意义(P>0.05)。结论在我国TS可作为一种新的宫颈病变筛查技术,用于扩大宫颈癌筛查人群范围。
Objective To investigate and compare the clinical application value of cancer screening system-Truscreen(TS)and cervical smear as well as liquid based cytology test(TCT)in the screening of cervical cancer.Methods A total of 398 patients with cervical lesion were randomly divided into two groups.The 198 patients in group A were examined by TS and cervical smears,respectively,however,the other 200 patients in group B were examined by TS and TCT,respectively.Taking pathological examination results as a golden standard to compare the sensitivity and specificity in the three kinds of examination methods.Results The positive cases by TS and cervical smears examination in group A were 42 cases and 36 cases,respectively,and 41 cases were positive by pathological examination.The sensitivity was 87.80%,65.85%,respectively,and specificity was 96.18%,94.28%,respectively,the sensitivity of TS was superior to that of cervical smears and that of TCT,however,there was no significant difference in specificity among the three examination methods.Moreover the positive cases by TS and TCT examination in group B were 52 cases and 40 cases,respectively,and 48 cases were positive by pathological examination.The sensitivity was 87.50%,70.83%,respectively,and specificity was 93.43%,96.05%,respectively,the sensitivity of TS was superior to that of cervical smears and that of TCT,however,there was no significant difference in specificity among the three examination methods(P>0.05).Conclusion The TS can be used as an new screening technique for cervical lesions in our country,which can be used in wide-bound crowd screening of cervical cancer.
作者
宁雪朋
徐玉萍
邱巍峰
龚俭雪
何洁
NING Xuepeng;XU Yupin;QIU Weifeng(The Third Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050011,China)
出处
《河北医药》
CAS
2018年第6期921-924,共4页
Hebei Medical Journal
关键词
初善仪
宫颈刮片
液基细胞学
宫颈癌筛查
对比研究
Truscreen
cervical smears
liquid based cytology
the screening of cervical cancer
comparative study
