摘要
目的:观察验方滋肾活血安神方治疗围绝经期失眠症临床疗效及对患者性激素水平的影响。方法:将60例围绝经期失眠症患者随机分为观察组30例和对照组30例。观察组予以验方滋肾活血安神方加减治疗,对照组予以谷维素治疗,两组疗程均为2个月,观察治疗前后的临床疗效、睡眠质量、匹兹堡睡眠质量指数(PSQI)分值、性激素水平、艾司唑仑服用量的情况。结果:(1)观察组、对照组临床总有效率分别为86.67%和63.33%;组间临床疗效比较,观察组明显优于对照组(P<0.05)。(2)组间治疗前后比较,观察组睡眠质量及PSQI总分均明显较对照组改善,差异有统计学意义(P<0.05)。(3)组间治疗后比较,观察组卵泡刺激素(FSH)下降程度比对照组更加显著(P<0.05),治疗组雌二醇(E2)升高程度比对照组更加显著(P<0.05)。(4)组间治疗比较,治疗组艾司唑仑服用量较治疗前明显减少(P<0.05)。结论:验方滋肾活血安神方治疗围绝经期失眠症的疗效显著,在改善患者失眠症状的同时兼具有调节患者内分泌等作用。
Objective:To observe the clinical curative effect and the effect on the patient's sex hormone levels of introduction Zishen Huoxue An’shen recipe in treatment of perimenopausal insomnia.Methods:Sixty patients with menopausal insomnia were randomly divided into the observation group30cases and the control group30cases.The observation group was given the treatment of Zishen Huoxue An’shen recipe,the control group was treated with oryzanol,two groups of a course of2months.The clinical efficacy,sleep quality,Pittsburgh sleep quality index(PSQI)score,Sex hormone level,Estazolam dose were observed before and after treatment.Results:Total effective rate in the treatment group was86.67%,control group,the clinical total effective rate was63.33%.The clinical effect of the group was compared,and the observation group was significantly better than the control group(P<0.05).Comparison between groups before and after treatment,observation group of sleep quality,sleep time,sleep time,sleep efficiency,sleep disturbance,hypnotic drugs,daytime dysfunction and total scores of PSQI were significantly compared with control group,the difference was statistically significant(P<0.05).After treatment,the observed group FSH decreased significantly more than the control group(P<0.05).The treatment group E2was significantly higher than the control group compared to the control group(P<0.05).Compared with the treatment group,the dosage of estazolam in the treatment group was significantly reduced compared with that of the treatment group(P<0.05).Conclusion:The effect of Zishen Huoxue An’shen recipe on the treatment of menopausal insomnia is remarkable.While improving the symptoms of insomnia,it can also be used to regulate the endocrine function of the patient.
作者
郭锦荣
田俊
Guo Jinrong;Tian Jun(Zhoupu Hospital Affiliated to Shanghai Health College,Shanghai 201318)
出处
《陕西中医》
2018年第1期17-19,共3页
Shaanxi Journal of Traditional Chinese Medicine
基金
上海市浦东新区人才培养项目(PDZYXK-6-2014039)
上海健康医学院种子基金项目(HMSF-17-22-045)
上海市浦东新区周浦医院重点学科(ZP-XK-2015B-5)
关键词
围绝经期/并发症
失眠/中医药疗法
@滋肾活血安神方
睡眠质量
Perimenopause/complications
Insomnia/traditional Chinese medicine therapy
@Zishen Huoxue An’shen recipe
Sleep quality
