摘要
目的:研究腹腔镜手术对直肠癌患者血清炎症因子、氧化应激水平及免疫功能的影响。方法:80例直肠癌患者随机分为对照组(n=40)和观察组(n=40),对照组行开腹手术治疗,观察组接受腹腔镜手术治疗。比较手术前后两组血清炎症因子、氧化应激及免疫功能水平。结果:术前,两组的血清hsCRP、IL-6、TNF-α、MDA、SOD、CD3+、CD4+、CD8+、CD4+/CD8+水平比较,差异无统计学意义(P>0.05)。两组术后血清hs-CRP、IL-6、TNF-α水平先升高后降低,术后1、3d时均显著高于术前,且观察组低于对照组同时间点(P<0.05)。两组术后血清MDA水平先升高后降低,SOD水平先降低后升高;两组MDA水平在术后1、3d时均显著高于术前,且观察组显著低于对照组同时间点(P<0.05);两组SOD水平在术后1、3d时均明显低于术前,且同时间点比较观察组明显高于对照组(P<0.05)。两组术后T淋巴细胞水平:CD3+、CD4+及CD4+/CD8+水平先降低后升高,术后1d、术后3d时均明显低于术前,且观察组术后1、3d时CD3+、CD4+及CD4+/CD8+水平明显高于对照组同时间点,差异比较有显著性(P<0.05)。两组患者术后血清CD8+水平先升高后降低,术后1、3d时较术前均明显升高,且观察组术后1、3d时CD8+水平明显低于对照组同时间点,差异比较有显著性(P<0.05)。结论:与传统开腹手术相比,腹腔镜手术能减轻患者炎症、应激反应及免疫抑制作用,整体效果较好,具有重要的临床价值。
Objective:To investigate the effects of laparoscopy on inflammatory factor、oxidative stress and immune function inpatients with rectal cancer.Methods:According to random data table method,80cases of rectal cancer were randomly divided into the control group(n=40)and observation group(n=40),patients in the control group were given conventional open surgery and the control group received routine surgery.The level of the serum inflammatory factor,oxidative stress and immune function before and after surgery were compared.Results:The levels of serum hs CRP,IL6,TNFα,MDA,SOD,CD3+,CD4+,CD8+and CD4+/CD8+in the two groups before treatment were not statistically significant(P>0.05).The levels of serum hs CRP,IL6and TNFαin the two groups were increased at first and then decreased,which were significantly higher than those in the same group before operation at1day and3days(P<0.05)and the observation group levels were significantly higher than those in the control group after1day and3days(P<0.05).The level of serum MDA increased first and then decreased in both groups,and the levels of SOD decreased first and then increased in two groups;the levels of MDA in the two groups were significantly higher than those before operation at1day and3days,and the observation group was significantly lower than the control group at the same time(P<0.05);the levels of SOD in the two groups were significantly lower than those before operation at1day and3days,and the observation group was significantly higher than the control group at the same time.The levels of serumCD3+,CD4+及CD4+/CD8+in the two groups were decreased at first and then increased,which were significantly lower than those in the same group before operation at1day and3days(P<0.05);and the observation group levels were significantly higher than those in the control group after1day and3days(P<0.05).The levels of serum CD8+in the two groups were increased at first and decreased subquently,which were significantly higher than those in the same group before operation at1day and3days(P<0.05)and the observation group levels were significantly lower than those in the control group after1day and3days(P<0.05).Conclusion:Compared with traditional open surgery,laparoscopic resection can light the patient's inflammation,stress response and immune suppression,and the overall effect is better which has important clinical value.
作者
戴刚
蔡一亭
高铭
张捷
龚庆豪
张超峰
DAI Gang;CAI Yi ting;GAO Ming;ZHANG Jie;GONG Qing hao;ZHANG Chao feng(Department of General Surgery, Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiaotong University, Shanghai 202150, China)
出处
《海南医学院学报》
CAS
2017年第17期2361-2364,共4页
Journal of Hainan Medical University
基金
上海卫生局课题面上项目(2015-323)~~
关键词
腹腔镜手术
直肠癌
炎症因子
氧化应水平
免疫功能
laparoscopic surgery
rectal cancer
inflammatory factor
oxidative stress
immune function
