摘要
目的:Q开关Nd:YAG 1 064nm激光(Q-switched Nd:YAG laser,QSNY)是治疗黄褐斑的常用手段,该系统评价基于随机对照试验(Randomized controlled trial,RCT)评价QSNY联合氨甲环酸在治疗黄褐斑中的作用。方法:使用Pubmed,EMBASE,CENTRAL,ISI Web of Science,Wanfang和CNKI来检索关于氨甲环酸和黄褐斑的RCT。结局指标包括临床治愈率、复发率和副作用发生率,并使用Rev Man5.3软件进行Meta分析。结果:该Meta分析共纳入11篇RCT,包含526例QSNY联合氨甲环酸组患者,489例QSNY组患者。相比单用QSNY,QSNY联合氨甲环酸有着更高的临床治愈率(RR 1.98,95%CI 1.74,2.26),更少的副作用(RR 0.38,95%CI 0.24,0.62),且复发率更低(RR 0.36,95%CI 0.16,0.77)。结论:氨甲环酸联合QSNY在临床疗效、减少副作用及复发率等方面均显著优于单用QSNY。
Objective Q-switched Nd:YAG laser(QSNY)is commonly used in the treatment of melasma,our current studyaims to evaluate the efficacy and safety of TA combined with QSNY in treating melasma based on randomized controlled trials(RCTs).Methods A comprehensive literature search was performed in Pubmed,EMBASE,CENTRAL,ISI Web of Science,Wanfang and CNKI to identify the RCTs of TA in the treatment of melasma.Outcome assessments included clinically effectiverate,recurrence rate and adverse effects.Meta-analysis was conducted via RevMan5.3software.Results Our current studyincluded a total of11RCTs comprising526patients in QSNY/TA groups and489patients in QSNY groups.When comparedwith QSNY therapy,TA combined with QSNY showed significantly higher clinically effective rate(RR1.98,95%CI1.74,2.26),significantly fewer adverse effects(RR0.38,95%CI0.24,0.62)and significantly lower recurrence rate(RR0.36,95%CI0.16,0.77).Conclusion TA combined with QSNY was better than QSNY alone in treating melasma,evidenced by significantlyhigher clinically effective rate,significantly reduced recurrence rate and fewer adverse events.
作者
王冰倩
吕正涛
LV Zheng-tao;WANG Bing-qian(Department of Orthopedics,Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,Hubei,China;First Clinical College,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China;)
出处
《中国美容医学》
CAS
2017年第6期82-87,共6页
Chinese Journal of Aesthetic Medicine
