摘要
目的:探讨雷公藤多苷联合缬沙坦对糖尿病肾病的临床效果,为临床治疗糖尿病肾病提供可靠参考。方法:取我院2015年4月-2016年1月医治的67例患者的临床资料为研究对象,以数字表法随机分为研究组(34例)和对照组(33例),对照组行雷公藤多苷治疗,研究组行雷公藤多苷、缬沙坦联合用药,观察两组患者治疗前后24h尿蛋白、血肌酐、内生肌酐清除率、血白蛋白及不良反应等情况。结果:治疗后两组患者24h尿蛋白、血白蛋白均明显改善,且研究组优于对照组,同组内、两组间比较,差异均有统计学意义(P<0.05);血肌酐、内生肌酐清除率等均无明显变化,差异均无统计学意义(P>0.05),研究组不良反应率低于对照组,差异无统计学意义(P>0.05)。结论:雷公藤多苷联合缬沙坦治疗糖尿病肾病效果明显,不良反应率低,具有临床应用价值。
Objective: To explore the clinical effect of tripterygium wilfordii polyglycoside plus valsartan on diabetic nephropathy.Methods: 67 patients were randomly divided into study group (34 cases) and control group (33 cases); and the urinary protein, serum creatinine,endogenous creatinine clearanle rate, albumin and adverse reactions were observed before and after treatment in groups. Results: After treatment,24h urine protein and albumin were significantly improved in both groups, and those in the study group were better than the control group (P<0.05);serum creatinine, endogenous creatinine clearanle showed no significant difference (P>0.05). The rate of adverse reactions in the study group was lower (P>0.05). Conclusion: Tripterygium wilfordii polyglycoside plus valsartan is effective on diabetic nephropathy.
出处
《中医临床研究》
2016年第32期64-66,共3页
Clinical Journal Of Chinese Medicine
关键词
雷公藤多苷
缬沙坦
糖尿病肾病
临床观察
Tripterygium glycosides
Valsartan
Diabetic nephropathy
Clinical observation
