摘要
目的研究天冬氨酸特异性半胱氨酸蛋白酶(Caspase)-3mRNA在脑挫裂伤患者神经细胞中的表达与预后的关系。方法应用原位杂交技术检测脑组织15例Caspase-3mRNA的表达情况。结果均有不同程度的Caspase-3mRNA表达,死亡组表达值较存活组明显升高。两组之间表达差异有显著性意义。结论脑挫裂伤后Caspase-3mRNA表达程度较高,Caspase-3mRNA过度表达在脑挫裂伤后神经细胞凋亡的调控中起一定的作用。
Objective To investi ga te the expression of Caspase-3mRNA in human brain after head injury and its cl inic pathological s ig-nificance.Methods We used hybridization technique in s itu to detect the expression of Caspase-3mRNA.Results All of the 15patient s were Caspase-3mRNA positive,Caspase-3mRNA was increased in patients with t raumatic brain injury who survived v ersus those who died(P<0.05).Conc lusion The Caspase-3appears to contribute to the mechanisms of cell death in h um an after brain contusion and this con clusion will provide therapeutic target s fo r traumatic brain injury.
出处
《中国临床康复》
CSCD
2002年第18期2698-2699,共2页
Chinese Journal of Clinical Rehabilitation
