摘要
目的分析左氧氟沙星治疗耐多药肺结核的疗效和不良反应。方法 100例耐多药肺结核患者,随机分为观察组和对照组,各50例。对照组采用常规治疗,观察组在对照组基础上使用左氧氟沙星治疗。比较两组患者治疗后的转阴情况、肺部病灶吸收效果以及不良反应发生情况。结果观察组患者治疗3、12、18个月时的转阴率均高于对照组,差异均具有统计学意义(χ2=9.458、11.111、7.162,P<0.05)。观察组患者肺部病灶总吸收率86%高于对照组的62%,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率30%低于对照组的70%,差异具有统计学意义(χ2=16.000, P<0.05)。结论左氧氟沙星治疗耐多药肺结核具有较好的临床效果,不良反应发生率低,值得推广使用。
Objective To analyze the clinical efficacy and adverse reactions of Levofloxacin in the treatment of multi drug resistant pulmonary tuberculosis. Methods A total of 100 cases of multi drug resistant pulmonary tuberculosis were randomly divided into observation group and control group, 50 cases in each group. The control group received conventional treatment. The observation group was treated with Levofloxacin on the basis of the control group. The negative conversion, absorption effect of pulmonary lesions and adverse reactions after treatment between the two groups were compared. Results The negative conversion rate of the observation group after 3, 12 and 18 months of treatment were significantly higher than those of the control group, the differences were statistically significant（χ^2=9.458, 11.111, 7.162, P〈0.05）. The total absorption rate of pulmonary lesions in the observation group was 86%, which was significantly higher than 62% in the control group, the difference was statistically significant（P〈0.05）. The incidence of adverse reactions in the observation group was 30%, which was significantly lower than 70% in the control group, the difference was statistically significant（χ^2=16.000, P〈0.05）. Conclusion Levofloxacin has a good clinical effect in the treatment of multi drug resistant pulmonary tuberculosis, the incidence of adverse reactions is low, it is worthy of promotion and use.
作者
马薇薇
MA Wei-wei(Chengdu Guoguang Electric Limited by Share Ltd Hospital,Chengdu 610051,China)
出处
《中国实用医药》
2018年第30期11-13,共3页
China Practical Medicine
关键词
左氧氟沙星
耐多药肺结核
联合用药
Levofloxacin
Multi drug resistant pulmonary tuberculosis
Drug combination
