摘要
目的探讨前列腺特异抗原前体(proPSA)血清表达水平在预测前列腺癌骨转移中的意义。方法选取184例前列腺癌患者为研究对象,49例发生骨转移的患者纳入前列腺癌骨转移组,135例未发生骨转移患者纳入非前列腺癌骨转移组,采用酶联免疫吸附试验检测proPSA、游离前列腺特异抗原(fPSA)、总前列腺特异抗原(tPSA)及血清良性前列腺特异抗原(BPSA)水平,并比较以上指标对前列腺癌骨转移的诊断价值。结果前列腺癌骨转移组的proPSA、BPSA、tPSA、proPSA/tPSA、fPSA/tPSA与非前列腺癌骨转移组比较,差异均有统计学意义(P<0.05)。proPSA与fPSA、BPSA、tPSA、proPSA/tPSA、fPSA/tPSA预测前列腺癌骨转移价值的两两比较中,除fPSA/tPSA与proPSA预测前列腺癌骨转移价值差异无统计学意义外(P>0.05),其余指标与proPSA比较,差异均有统计学意义(均P<0.05),表现为proPSA的诊断价值更优。结论 proPSA血清表达水平在预测前列腺癌骨转移中有一定的临床意义,但结合诊断指标本身的特征及患者tPSA水平对相应的筛检指标进行进一步筛选,可能具有更实际的临床应用价值。
Objective To investigate the predictive value of serum precursor of prostate-specific antigen（proPSA）level in predicting bone metastasis of prostate cancer.Methods A total of 184 patients with prostate cancer were selected in this study,49 cases with bone metastases in bone metastases group,and 135 cases without bone metastases in non-bone metastases group.ProPSA,free prostate specific antigen（fPSA）,total prostate specific antigen（tPSA）and benign prostate specific antigen（BPSA）were detected by ELISA,and compared their value of predicting the bone metastasis of prostate cancer.Results ProPSA,BPSA,tPSA,proPSA/tPSA and proPSA/tPSA in bone metastases group and non-bone metastases group had statistically significant（all P0.05）.Excepting fPSA/tPSA,other indicators of value for predicting bone metastasis of prostate cancer had statistically significant differences with proPSA（all P0.05）.Conclusion The serum level of proPSA might be of clinical significance in predicting the bone metastasis of prostate cancer.However,the combination of the characteristics of the diagnostic indicator itself and the tPSA level of the patients should be further screened for the corresponding screening indexes,which might have a more practical clinical value.
作者
王曙
陆毅
沈明康
吕承勋
翦晓明
WANG Shu;LU Yi;SHEN Mingkang;LYU Chengxun;JIAN Xiaoming(Department of Urinary Surgery,East City Hospital of Yangpu District,Shanghai 200438,China)
出处
《检验医学与临床》
CAS
2018年第21期3228-3231,共4页
Laboratory Medicine and Clinic
关键词
前列腺特异抗原前体
前列腺癌
骨转移
预测
precursor of prostate-specific antigen
prostate cancer
bone metastasis
predict
