摘要
为了解真实世界银花泌炎灵片用药人群的临床特征，该研究采集2006年2月—2015年12月全国16家三级甲等医院信息系统（hospital information system，HIS）中银花泌炎灵片用药患者信息，数据规范化后，进行描述性分析。发现5 312例患者中女性（63．67％）多于男性（36．33％）。年龄中位数为49岁，18～65岁者占74．52％。入院科室主要为妇产科（28．71％）和泌尿科（28．43％）。单次剂量中位数2g，占49．55％；每日剂量中位数6g；88．80％患者疗程在7d以下。住院时间中位数为12d，7～14 d最多（41．70％）。住院费用医保支付占80．22％，住院总费用中位数为12 211．47元。患者合并良性肿瘤（27．36％）和恶性肿瘤（15．56％）占较高比例，其次是泌尿系梗阻（15．49％）、泌尿系结石（10．52％）。最常见的中医证候为：湿热内蕴证（32．46％）、肝肾亏虚证（15．33％）、脾虚湿困证（15．01％）。临床多与抗生素、中药清热剂、补益剂等合并使用。出院结局，治愈者占44．22％，好转者占51．05％。可以看出应用银花泌炎灵片的住院患者多为成年人，女性较多，多合并肿瘤、泌尿道梗阻或结石。中医证候以湿热内蕴、肝肾亏虚及脾虚湿困为主。临床多与抗生素联合应用，用法用量基本符合药品说明书。基于HIS真实世界的研究结果为银花泌炎灵片进一步规范用药提供思路和参考。
Clinical characteristics of Yinhua Miyanling Pian user group were analyzed based on real world hospital information system （HIS） database. The information was collected from the HIS in sixteen hospitals of grade Ⅲ-A. Normalizing the data and descriptive analysis was performed. Among the 5 312 cases, female patients （63.67%） were more than male patients （36.33% ）. The median age was 49 years old. The age of 18-65 accounted for 74.52%. The patient was admitted to the hospital＇s department of obstetrics and gynecology（28.71%） and urology（28.43%）. The median single dose is 2 g, accounted for 49.55%. The median daily dose is 6 g. 88.80% of patients were treated for less than 7 d. The median hospitalization were 12 d, most were 7-14 d accounted for 41.70%. Most hospitalization expenses payment by medicare, accounted for 80.22%. The median hospitalization expenses was 12 211.47 RMB. Most patients with benign tumor（27.36%） and malignant tumor（15.56%）, next is the obstruction of urinary tract （ 15.49% ） and urinary calculi（ 10.52% ）. The most common syndromes were damp heat syndrome（32.46%） , liver and kidney deficiency syndrome（ 15.33% ） and splenasthenic fluid-retention syndrome（ 15.01% ）. Clinical use is combined with antibiotics, as well as traditional Chinese medicine heat clearing agents, tonic drugs and so on. Finally, 44.22% were cured and 51.05% were better.Most of the drug users were adults, and mostly were female. Most with the tumor, urinary tract obstruction or stones. TCM syndrome is mainly characterized by dampness and heat, deficiency of liver and kidney, and dampness of spleen. In clinical practice, it was mainly combined with Western medicines, and Chinese medicines were also a-vailable. And most are combined with antibiotics. The medication basically conforms to the drug instruction. Based on the results of the real world HIS ,Yinhua Miyanling Pian could provide theidea and reference for regulating the medication in adolescent patients.
作者
孙锦
谢雁鸣
刘峘
张寅
张永升
庄严
SUN Jin,XIE Yan-ming,LIU Huan,ZHANG Yin,ZHANG Yong-sheng,ZHUANG Yan(1.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;2.Institute of Basic Medical Science of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;3.School of Statistics, Renmin University of China, Beijing 100872, China; 4.The PLA Navy General Hospital, Beijing 100048, China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第16期3391-3396,共6页
China Journal of Chinese Materia Medica
基金
中国中医科学院自主选题项目(PY1303,Z0016)
国家“重大新药创制”科技重大专项(2015ZX09501004-001-002)
关键词
银花泌炎灵片
真实世界
医院信息系统/HIS
临床特征
Yinhua Miyanling Pian
real world study
hospital information system/HIS
clinical characteristics
