摘要
目的研究无创通气联合血液净化治疗对急性呼吸窘迫综合征患者炎症因子与氧化应激反应的影响。方法选取我院2015年1月~2017年5月收治的78例急性呼吸窘迫综合征患者作为研究对象,按照随机数字表法分为对照组(n=39)和观察组(n=39),对照组采用无创通气治疗法,观察组采用无创通气联合血液净化治疗法。比较两组的炎症因子水平、氧化应激反应指标。结果治疗后,观察组的TNF-α、IL-1β、IL-6炎症因子水平低于对照组,差异有统计学意义(P<0.05)。观察组的CRP水平高于对照组,SOD、GSH-Px降低程度均低于对照组,差异有统计学意义(P<0.05),观察组MDA提升幅度低于对照组,差异有统计学意义(P<0.05)。结论为急性呼吸窘迫综合征患者提供无创通气联合血液净化治疗有助于稳定炎症因子水平及氧化应激反应,确保临床疗效,促进患者早日康复,值得推广应用。
Objective To study the influence of non-invasive ventilation combined with blood purification on inflamma- tory factors and oxidative stress in patients with acute respiratory distress syndrome. Methods All of 78 patients with a- cute respiratory distress syndrome admitted into our hospital from January 2015 to May 2017 were selected as the study subjects. They were divided into the control group （n=39） and observation group （n=39） according to the random num- ber table method. The control group was treated with non-invasive ventilation, and the observation group was treated with non-invasive ventilation combined with blood purification. The levels of inflammatory factors and oxidative stress reaction indexes were compared between the two groups. Results After treatment, the levels of TNF-α, IL-1β and IL- 6 inflammatory factors in the observation group were lower than those in the control group, and the differences were statistically significant （P〈0.05）. The CRP level in the observation group was higher than that in the control group, and the degree of reduction of SOD and GSH-Px in the observation group were lower than those in the control group, and the differences were statistically significant （P〈0.05）. The increase of MDA in the observation group was lower than that in the control group （P〈0.05）. Conclusion non-invasive ventilation combined with blood purification treatment for pa- tients with acute respiratory distress syndrome can help to stabilize inflammatory factors and oxidative stress, ensure clinical efficacy, and promote the early recovery of pa- tients, which is worthy of popularization and application.
作者
朴艺花
李金华
孟继圣
张兴宇
金明根
PU Yi-hua;LI Jin-hua;MENG Ji-shen;ZHANG Xing-yu;JIN Ming-gen(Department of Critical Care Medicine,Affiliated Hospital of Yanbian University,Jilin Province,Yanji 133000,China;Department of Critical Care Medicine of ICU,Qianwei Hospital of Jilin Province,Changchun 130012,China)
出处
《中国当代医药》
2018年第28期21-24,共4页
China Modern Medicine
基金
吉林省自然科学基金项目(20160101185JC)
关键词
急性呼吸窘迫综合征
无创通气
血液净化
炎症因子
氧化应激反应
疗效
Acute respiratory distress syndrome
non- invasive ventilation
Blood purification
Inflammatory factors
Oxidative stress response
Efficacy
