摘要
目的分析异甘草酸镁注射液治疗高胆红素血症急性药物性肝损伤(ADILI)患者的临床疗效。方法选取我院收治的ADILI伴高胆红素血症患者80例,根据治疗方法分组,对照组47例采用常规药物治疗;观察组33例,在常规治疗基础上加用异甘草酸镁注射液治疗。比较两组患者的治疗效果。结果两组的治疗总有效率无统计学差异(P>0.05);治疗后,两组患者的ALT、AST、ALP、γ-GGT、TB、DB水平均明显低于治疗前,且观察组ALT、ALP、γ-GGT、DB水平均明显低于对照组(P<0.05)。结论异甘草酸镁注射液治疗ADILI伴高胆红素血症疗效更显著,肝功能恢复快且安全性高。
Objective To analyze the clinical efficacy of magnesium isolicate injection in the treatment of acute drug-induced liver injury （ADILI） in patients with hyperbilirubinemia. Methods A total of 80 cases of ADILI patients withhyperbilirubinemia were selected in our hospital. According to the treatment methods, 47 cases in the control group weretreated with conventional medicine, and 33 cases in the observation group were treated with magnesium isolicate injectionon the basis of conventional treatment. The treatment effects were compared between the two groups. Results There was nostatistical difference in the total effective rate of treatment between the two groups （P〉0.05）. After treatment, the levels ofALT, AST, ALP, γ-GGT, TB and DB of the two groups were significantly lower than those before treatment, and the levelsof ALT, ALP, γ-GGT and DB in the observation group were significantly lower than those in the control group （P〈0.05）.Conclusion Magnesium isolicate injection is more effective in the treatment of ADILI with hyperbilirubinemia, and therecovery of liver function is faster, with high safety.
作者
赵欣
张娟
ZHAO Xin, ZHANG Juan(Pharmacy Department, Xi＇an No.5 Hospital, Xi＇an 710082, China)
出处
《临床医学研究与实践》
2018年第28期46-47,共2页
Clinical Research and Practice
