摘要
目的:探讨和肽素(copeptin)联合脑钠肽前体(pro-BNP)在双水平无创正压通气(BIPAP)治疗急性心力衰竭中的意义。方法:120例急性心力衰竭患者按照Kiliip分级方法分为3组:Killip 2级(n=40)、Killip 3级(n=40)、Killip 4级(n=40),每级40例随机分为常规治疗组(n=20)及无创通气组(n=20),分别在各级中比较常规治疗组及无创通气组的copeptin、pro-BNP水平,同时在治疗第3天、第7天比较所有常规治疗组及无创通气组的再Killip分级情况。结果:Killip 4级与Killip 3级的copeptin、pro-BNP水平明显高于Killip 2级患者,差异有统计学意义(P<0.05);Killip 4级的copeptin、pro-BNP水平明显高于Killip 3级,差异有统计学意义(P<0.05);copeptin水平和pro-BNP呈正相关(r=0.803,P<0.01),在治疗第3天、第7天,无创通气组的疗效优于常规治疗组。结论:copeptin与pro-BNP可以很好地评价经BIPAP治疗后患者心力衰竭的程度,可以作为早期诊断及预后疗效的判定指标。
Objective：To investigate the significance of copeptin combined with pro-BNP in the treatment of acute heart failure with BIPAP.Method：One hundred and twenty patients with acute heart failure were divided into three groups according to Killip classfication：Killip 2 nd level（n=40）,Killip 3 rd level（n=40）,Killip 4 th level（n=40）.Each 40 cases per level were divided into two groups：the routine treatment group（n=20）and the non-invasive ventilation group（n=20）.The copeptin and pro-BNP levels were compared respectively in the routine treatment group and the non-invasive ventilation group.The Killip grades of the two groups were compared on the 3 rd and7 th day of treatment.Result：The levels of copeptin and pro-BNP in Killip 4 th level and Killip 3 rd level were significantly higher than those in Killip 2 nd level.The difference was statistically significant（P 0.05）.The levels of copeptin and pro-BNP of Killip 4 th level were significantly higher than those of Killip 3 rd level（P〈0.05）.There was a positive correlation between the content of copeptin and pro-BNP（r=0.803,P〈0.01）,On the 3 rd and 7 th day of treatment,the curative effect of non-invasive ventilation group was better than that of routine treatment group.Conclusion：The copeptin and pro-BNP can be used to evaluate the severity of acute heart failure treated with BIPAP,and can also be used to make early diagnosis and assess prognosis.
作者
陶新
张超
高洁
TAO Xin;ZHANG Chao;GAO Jie(Department of Emergency Medicine,Nanxiang Hospital,Jiading District,Shanghai,201802,China)
出处
《临床急诊杂志》
CAS
2018年第8期533-536,共4页
Journal of Clinical Emergency
基金
2015年上海市嘉定区卫计委立项科研课题(No:2015-KY-05)
关键词
和肽素
脑钠肽前体
急性心力衰竭
copeptin
pro-B-type natriuretic peptidelacute heart failure
