摘要
泪腺上皮性肿瘤中常见的良、恶性肿瘤分别是泪腺多形性腺瘤和腺样囊性癌。泪腺多形性腺瘤易复发、恶变，腺样囊性癌单纯手术疗效不满意，易复发，预后差。分子生物学研究发现，癌基因PLAG1和HMGA2对多形性腺瘤的诊断有较高的敏感性和特异性；MYB基因表达可作为腺样囊性癌的分子诊断指标；抑癌基因INK4a-ARF、信号通路白介素-6（interleukin-6, IL-6）/JAK/STAT3和Notch、基质金属蛋白酶和环氧合酶-2等，在泪腺上皮性肿瘤发生发展、复发、恶变、转移中均有一定作用。
Epithelial tumor of lacrimal gland is a common orbital tumor, and the common benign and malignant tumors are respectively lacrimal pleomorphic adenoma and adenoid cystic carcinoma. Lacrimal pleomorphic adenoma is prone to relapse, malignant change, adenoid cystic carcinoma is not satisfactory to operate simply, easy to relapse, and poor prognosis. In recent years, molecular biology studies have found that oncogene PLAG1 and HMGA2 have high sensitivity and specificity in the diagnosis of pleomorphic adenoma. MYB gene expression can be used as the molecular diagnostic index of adenoid cystic carcinoma. Tumor-suppressor genes INK4a - ARF, signaling pathways, such as IL-6 / JAK/STAT3 and Notch, matrix metalloproteinases （MMP） and cyclooxygenase 2 （COX-2） and so on, have some effect on the development, recurrence, metastasis and transformation of the epithelial tumor of lacrimal gland.
作者
王婧
朱豫
WANG Jing;ZHU Yu(Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《国际眼科纵览》
2018年第4期269-273,共5页
International Review of Ophthalmology
基金
河南省基础与前沿技术研究计划项目（122300410037）
关键词
泪腺上皮性肿瘤
多形性腺瘤
腺样囊性癌
lacrimal epithelial tumor
pleomorphic adenoma
adenoid cystic carcinoma
