摘要
目的:采用能谱CT定量参数检测方法评估骨质疏松并探讨能谱CT定量参数与骨生物力学的相关性。方法:选取SPF级别雌性SD大鼠20只,采用随机数字表法分为2组:假手术组(A组)、单纯去势组(B组),每组10只。B组进行双侧卵巢切除法制作骨质疏松大鼠模型,继续饲养3月,双能X线骨密度仪测定大鼠全身骨密度确定模型成功,然后能谱CT定量参数测完在体骨密度后处死大鼠,收集腰椎L4去除附件椎体,行腰椎压缩实验后灰化称量灰重,将能谱CT不同定量参数(羟基磷灰石-水基物质对、钙-水基物质对、铁-水基物质对、血-水基物质对)所得的骨密度值分别与灰重密度值、L4压缩试验所得生物力学值进行相关性分析。结果:能谱CT定量参数测得骨密度值与灰重密度值相关性分析可得,采用羟基磷灰石-水基物质对、钙-水基物质对相关性较强,且羟基磷灰石-水基物质对相关性最好,而铁-水基物质对、血-水基物质对相关性较差;能谱CT定量参数与生物力学相关性分析同样可得出在采用羟基磷灰石-水基物质对时弹性模量、最大载荷相关性最好。结论:能谱CT成像所得骨密度值与灰重密度值、骨生物力学变化趋势均一致。能谱CT成像在采用羟基磷灰石-水基物质对时,与灰重密度值相关性最好,同样也与骨生物力学相关性最好,是评价骨强度的最佳定量参数。
Objective To evaluate osteoporosis by the detection of energy spectrum CT quantitative parameters, and explore the correlation between energy spectrum CT quantitative parameters and bone biomechanics. Methods Twenty female SpragueDawley rats without special pathogen were selected and randomly divided into two groups, namely sham operation group（group A） and simple castration group（group B）, with 10 rats in each group. The rats in group B were subjected to bilateral oophorectomy to establish an osteoporotic rat model and continued to be fed for 3 months. Dual-energy X-ray absorptiometry was used to measure the whole body bone mineral density（BMD） in order to determine whether the model was successfully established. After the in vivo BMD was measured with energy spectrum CT quantitative parameters, the rats were sacrificed and lumbar vertebra L4 was collected for further experiment and the attachment vertebral body was removed. After the lumbar compression test, the ash weight was measured. The correlation of BMD obtained by different energy spectrum CT quantitative parameters（hydroxyapatite-water-based material pair, calcium-water-based material pair, iron-water-based material pair and blood-waterbased material pair） with ash density values and the biomechanical values obtained from the L4 compression test were analyzed.Results The correlation analysis between BMD obtained by different energy spectrum CT quantitative parameters and ash density values showed that hydroxyapatite-water-based material pairs and calcium-water-based material pairs had strong correlations with the ash density values, and that hydroxyapatite-water-based material pairs had the best correlation, but iron-water-based material pairs and blood-based material pairs had poor correlations. The correlation analysis between energy spectrum CT quantitative parameters and biomechanics also showed that the correlation of base material with elastic modulus and the maximum load was the best when using hydroxyapatite-water-based material pairs. Conclusion The BMD obtained by energy spectrum CT imaging are consistent with the change trends of ash density values and bone biomechanics. The hydroxyapatite-water-based material pairs of energy spectrum CT imaging has the best correlation with the ash density values, and the best correlation with bone biomechanics, which makes it the best quantitative parameter for bone strength evaluation.
作者
董强
解琪琪
赵若辰
黄晓宇
李文洲
张祎年
潘亚文
DONG Qiang;XIE Qiqi;ZHAO Ruochen;HUANG Xiaoyu;LI Wenzhou;ZHANG Yinian;PAN Yawen(Lanzhou University,Lanzhou 730000,China;Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou 730000,China;Department of Orthopaedics,Lanzhou University Second Hospital,Lanzhou 730000,China;Department of Critical Care Medicine,Lanzhou University Second Hospital,Lanzhou 730000,China;Department of Radiology,Lanzhou University Second Hospital,Lanzhou 730000,China;Institute of Neurology,Lanzhou University,Lanzhou 730000,China)
出处
《中国医学物理学杂志》
CSCD
2018年第8期978-982,共5页
Chinese Journal of Medical Physics
基金
国家自然科学基金(81501116
81771297)
兰州大学第二医院萃英科技创新计划(CY2017-MS04/-MS12/-MS15)
关键词
能谱CT
灰重密度
骨生物力学
骨质疏松
相关性
energy spectrum CT
ash density
bone biomechanics
osteoporosis
correlation
