摘要
目的：探讨中药半夏泻心汤治疗慢性胃炎伴幽门螺杆菌感染的疗效及安全性。方法：选取2015年7月—2017年3月在本院进行治疗的慢性胃炎伴幽门螺杆菌感染患者92例,按随机数表法分为两组,各46例。对照组行常规西药治疗,观察组在对照组基础上予半夏泻心汤治疗,比较两组血清指标、疗效、根除率及不良反应情况。结果治疗前,两组血清指标[胃泌素-17（Gastrin-17,G-17）、胃蛋白酶原比值（Pepsinogen ratio,PGR）及胃蛋白酶原-Ⅰ（Pepsinogen,PGⅠ）]水平差异无统计学意义（P〉0.05）;治疗后,观察组G-17、PGR及PGⅠ水平均明显低于对照组,差异有统计学意义（P〈0.05）;观察组治疗总有效率91.30%（42/46）及根除率95.65%（44/46）均明显高于对照组的[76.09%（35/46）及80.43%（37/46）],差异有统计学意义（P〈0.05）;两组治疗期间均未出现明显不良反应。结论：在慢性胃炎伴幽门螺杆菌感染患者治疗过程中行中药半夏泻心汤治疗效果显著,可有效降低G-17、PGR及PGⅠ水平,提高根除率,且安全性较好。
Objective：To study the efficacy and safety of Chinese medicine Banxia Xiexin Decoction in treating chronic gastritis with Helicobacter pylori infection. Methods：A total of 92 patients with chronic gastritis treated with Helicobacter pylori infection who were treated in our hospital from July 2015 to March 2017 were selected as subjects. All the patients were divided into two groups according to random number table method,each group 46 cases. The patients in the control group were treated with conventional western medicine and the patients in the observation group were treated with Banxia Xiexin Decoction on the basis of the control group. The serum indexes,clinical efficacy,eradication rate and adverse reaction were compared and analyzed before and after treatment in both groups. Results：There was no significant difference in serum levels of gastrin-17（ G-17）,pepsinogen ratio（ PGR） or pepsinogen（ PGI） before treatment（ P〉0.05）. After treatment,the levels of G-17,PGR and PGⅠ in the observation group were significantly lower than those in the control group（ P〈0.05）. The total effective rate was 91. 30%（42/46） and the eradication rate was 95. 65%（44/46） in the observation group,which was significantly higher than that in the control group[76. 09%（35/46） and 80. 43%（37/46）],and the difference was statistically significant（P〈0.05）. There were no significant adverse reactions of the two groups（ P〉0.05）. Conclusion：For chronic gastritis with Helicobacter pylori infection in patients,traditional Chinese medicine Banxia Xiexin Decoction treatment effect is significant and can effectively reduce G-17,PGR and PGⅠ levels and improve the eradication rate,and has better safety.
作者
张伟
姜锐
王璐
ZHANG Wei;JIANG Rui;WANG Lu(Department of Traditional Chinese Medicine,The Second Affiliated Hospital of Qiqihar Medical School,Qiqihar 161000,Heilongjiang,China;Department of Dermatological,The Second Affiliated Hospital of Qiqihar Medical School,Qiqihar 161000,Heilongjiang,China)
出处
《辽宁中医杂志》
CAS
2018年第7期1424-1426,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
中药半夏泻心汤
慢性胃炎伴幽门螺杆菌感染
疗效
安全性
traditional Chinese medicine Banxia Xiexin Decoction
chronic gastritis with Helicobacter pylori infection
efficacy
safety
