摘要
目的:探讨替诺福韦酯联合拉米夫定治疗获得性免疫缺陷综合征合并乙型肝炎病毒(hepatitis B virus,HBV)感染的疗效。方法:选取2015年1月至2016年1月佳木斯传染病院收治的获得性免疫缺陷综合征合并HBV感染患者68例,按随机数字表法分为甲组和乙组,每组34例。甲组患者给予拉米夫定治疗,乙组患者在甲组的基础上加用替诺福韦酯治疗。观察两组患者治疗前后免疫球蛋白水平变化、CD4^+T淋巴细胞计数、人类免疫缺陷病毒(human immunodeficiency virus,HIV)RNA及HBV DNA载量和不良反应发生情况。结果:治疗后,乙组患者免疫球蛋白M、免疫球蛋白A和免疫球蛋白G水平明显高于甲组,差异均有统计学意义(P<0.05);治疗后,乙组患者CD4^+T淋巴细胞计数明显高于甲组,HIV RNA及HBV DNA载量明显低于甲组,差异均有统计学意义(P<0.05);甲组、乙组患者不良反应发生率分别为17.65%(6/34)、14.71%(5/34),差异无统计学意义(P>0.05)。结论:替诺福韦酯联合拉米夫定治疗获得性免疫缺陷综合征合并HBV感染的疗效突出,能提高患者免疫功能,降低机体中的病毒载量,促进患者康复,且安全性较高。
OBJECTIVE： To probe into the efficacy of tenofovir disoproxil fumarate combined with lamivudine in treatment of acquired immunodeficiency syndrome complicated with hepatitis B virus（ HBV） infection. METHODS：68 patients with acquired immunodeficiency syndrome complicated with HBV infection admitted into Jiamusi Infectious Hospital from Jan. 2015 to Jan. 2016 were extracted to be divided into group A and group B via the random number table,with 34 cases in each. Patients in group A were given lamivudine,while patients in group B additionally received tenofovir disoproxil fumarate based on the control group. Changes of immunoglobulin levels, CD4~＋T lymphocyte,human immunodeficiency virus（ HIV） RNA and HBV DNA load and incidence of adverse drug reactions of two groups were observed before and after treatment. RESULTS： After treatment, the IgM, IgA, IgG immunoglobulin levels in group B were significantly higher than those in the group A,with statistically significant differences（ P〈0. 05）. After treatment,the CD4~＋T lymphocytes in group B was significantly higher than that in group A,yet the HIV RNA and HBV DNA load of group B were significantly lower than those of group A,with statistically significant differences（ P〈0. 05）. The incidence of adverse drug reactions of group A and B were respectively 17. 65%（ 6/34） and 14. 71%（ 5/34）,the difference was not statistically significant（ P〉0. 05）.CONCLUSIONS： The efficacy of tenofovir disoproxil fumarate combined with lamivudine in treatment of acquired immunodeficiency syndrome complicated with HBV infection is significant,which can improve patients＇ immunity,reduce the viral load in the body and promote patients＇ rehabilitation with higher safety.
作者
杨凯
郭静微
YANG Kai;GUO Jingwei(Dept.of the Fifth Ward,Jiamusi Infectious Hospital,Heilongjiang Jiamusi 154007,China;Dept.of Dermatology,Jiamusi Central Hospital,Heilongjiang Jiamusi 154007,China)
出处
《中国医院用药评价与分析》
2018年第7期887-889,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
替诺福韦酯
拉米夫定
获得性免疫缺陷综合征
乙型肝炎病毒
Tenofovir disoproxil fumarate
Lamivudine
Acquired immunodeficiency syndrome
Hepatitis B virus
