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冠心病心力衰竭病人NYHA心功能分级和血清NT-proBNP及HRV各项指标的关系 被引量:73

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摘要 目的分析冠心病心力衰竭病人纽约心脏病协会(NYHA)心功能分级和血清N端脑钠素前体(NT-proBNP)及心率变异性(HRV)各指标的关系,探讨NT-proBNP和HRV各指标在冠心病心力衰竭病人病情评估中的作用。方法选择冠心病合并慢性心力衰竭的病人112例为观察组,28名健康人为对照组。检测HRV指标(SDNN、SDNNI、RMSSD、PNN50、三角指数)及NTproBNP。结果观察组血清NT-proBNP较对照组高,HRV指标较对照组低,除SDNNI外差异均有统计学意义。随着NYHA心功能分级的升高,血清NT-proBNP水平升高,各心功能分级间比较差异均有统计学意义(P<0.05);SDNN、SDNNI、RMSSD、PNN50、三角指数下降,心功能Ⅲ、Ⅳ级与Ⅰ、Ⅱ级比较差异均有统计学意义(P<0.05);其中PNN50在各级间比较差异均有统计学意义(P<0.05)。多元逐步回归分析,血清NT-proBNP、SDNN、PNN50及三角指数进入回归方程,是影响心功能分级的重要因素,回归方程(心功能分级)Y=4.364+1.843×10^(-4) NT—proBNP-0.013×SDNN-0.045×PNN50-0.025×三角指数。结论 NT-proBNP与HRV水平对冠心病病人的诊断及治疗具有积极意义。
机构地区 天津市人民医院
出处 《中西医结合心脑血管病杂志》 2018年第14期2058-2060,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
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