摘要
目的分析抗抑郁药和抗精神病药物所致QT间期延长情况。方法选取2013年5月-2015年3月间我院收治的接受抗抑郁药治疗的64例抑郁症患者作为观察1组,接受抗精神病药治疗的62例精神分裂症患者作为观察2组,选取同期入院尚未接受抗抑郁药、抗精神病药治疗的60例精神病患者作对照组,比较三组患者心电图检查情况。结果观察1组、观察2组与对照组患者QT延长率分别为20.3%、25.8%、1.7%,观察组1组与观察2组QT延长率均明显高于对照组,差异有统计学意义（P〈0.05）。观察1组与观察2组QTc测定结果均明显大于对照组,且观察2组QTc明显大于观察1组,差异均有统计学意义（P〈0.05）。结论抗抑郁药和抗精神病药物均可导致精神病患者QT间期延长,且抗精神病药物的影响更为明显,在用药时需严加把握药物适应证,合理用药,确保患者安全。
Objective To analyze the influences of antidepressants and antipsychotic drugs in prolonged QT interval. Methods From May 2013 to March 2015 in our hospital, 64 patients with depression who underwent antidepressant therapy were selected as the observation group 1; 62 patients with schizophrenia were selected as the observation group 2. At the same time, 60 patients with psychosis with no antidepressant were treated as the control group. The electrocardiogram results between the three group were compared. ResultsThe prolongation rates of QT interval in the observation group 1, 2 and the control group were 20.3%, 25.8% and 1.7%, respectively. The prolongation rate of QT interval in the observation group 1 and 2 were significantly higher than that in the control group, with significant differences（P〈0.05）. The QTc results of the observation group 1 and 2 were significantly higher than that of the control group, and the QTc results of the observation group 2 was significantly larger than that of the observation group 1, both with significant differences（P〈0.05）. ConclusionAntidepressants and antipsychotics can lead to prolonged QT interval in psychiatric patients, and the role of antipsychotic drugs is more significant. During the treatment, it is necessary to strictly control the drug indications and the rational use of drugs to ensure the safety of patients.
作者
石建喜
朱宏日
王瑞超
高明秀
周小东
Jianxi SHI;Hongri ZHU;Ruichao WANG;Mingxiu GAO;Xiaodong ZHOU(256^th Clinical Department,Bethune International Peace Hospital,Zhengding 050000,China)
出处
《心电图杂志（电子版）》
2015年第4期161-163,共3页
Journal of Electrocardiogram（Electronic Edition）
