摘要
目的比较玻璃体腔内注射雷珠单抗与康柏西普治疗湿性年龄相关性黄斑变性(AMD)的疗效。方法 80例AMD患者(共80眼)随机分为A组(雷珠单抗治疗)和B组(康柏西普治疗),比较2组的临床疗效和眼部并发症发生率。结果治疗1个月后,A组视力为(46.17±2.52),B组为(47.52±2.23),差异有统计学意义(P<0.05);治疗3个月后,2组视力比较无显著差异(P>0.05)。治疗1个月后,A组黄斑中心视网膜厚度为(368.79±40.42)μm,显著大于B组的(350.02±40.23)μm(P<0.05);治疗3个月后,2组黄斑中心视网膜厚度比较,差异无统计学意义(P>0.05)。B组脉络膜新生血管形成(CNV)渗漏改善率高于A组,眼部并发症总发生率低于A组(P>0.05)。结论康柏西普治疗湿性年龄相关性黄斑变性患者的前期效果优于雷珠单抗,但随着时间的延长,二者后期疗效相近。
Objective To compare the efficacy of intravitreous injection of ranibizumab and combaripide in the treatment of patients with wet age-related macular degeneration（ AMD）. Methods A total of 80 patients with wet AMD（ 80 eyes） were randomly divided into group A（ ranibizumab treatment） and group B（ compacept treatment）,and the clinical efficacy and incidence rate of ocular complications were compared between the two groups. Results After one month of treatment,the visual acuity of group A was（ 46. 17 ± 2. 52）,and was（ 47. 52 ± 2. 23） in group B,and there was significant difference（ P〈0. 05）. After 3 months of treatment,there was no significant difference in visual acuity between the two groups（ P〉0. 05）. After one month of treatment,the macular central retinal thickness in group A was（ 368. 79 ± 40. 42） μm,which was significantly higher than（ 350. 02 ± 40. 23） μm in group B（ P〈0. 05）. After 3 months of treatment,there was no significant difference in macular central retinal thickness between the two groups（ P〉0. 05）. The total improvement rate of CNV leakage in group B was significantly higher than that of group A,and the total incidence rate of eye complications was significantly lower than that of group A（ P〉0. 05）. Conclusion Conbespond shows a better therapeutic efficiency in early period than ranibizumab in the treatment of patients with wet age-related macular degeneration,but with the extension of time,the two medicines show a similar efficiency in the late stage.
作者
舒宝君
雷淑红
陈瑜
朱佳丽
SHU Baojun;LEI Shuhoog;CHEN Yu;ZHU Jiali(Ophthalmologic Center,Shangluo International Medical Center Hospital in Shaanxi Province,Shangluo,Shaanxi,72600)
出处
《实用临床医药杂志》
CAS
2018年第17期93-95,98,共4页
Journal of Clinical Medicine in Practice
