摘要
目的探讨益血生胶囊联合兔抗人胸腺细胞免疫球蛋白治疗再生障碍性贫血的临床疗效。方法选取2015年6月—2016年6月天津市第五中心医院收治的再生障碍性贫血患者126例,随机分成对照组(63例)和治疗组(63例)。对照组患者静脉滴注兔抗人胸腺细胞免疫球蛋白,2.5 mg/kg加入生理盐水250 mL,滴注时长>4 h,1次/d,连续治疗5 d。治疗组患者在对照组基础上口服益血生胶囊,4粒/次,3次/d。两组患者均治疗5 d。观察两组患者临床疗效,同时比较治疗前后两组患者血象指标、免疫指标和不良反应。结果治疗后,对照组临床有效率为82.54%,显著低于治疗组的96.82%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的白细胞计数、血小板计数和血红蛋白水平均显著升高(P<0.05),且治疗组患者上述指标明显高于对照组(P<0.05)。治疗后,两组患者CD4^+计数显著升高(P<0.05),CD8^+计数显著降低(P<0.05),且治疗后治疗组患者上述免疫指标明显好于对照组(P<0.05)。治疗期间,对照组患者不良反应发生率为20.63%,显著高于治疗组患者的6.35%,两组比较差异具有统计学意义(P<0.05)。结论益血生联合兔抗人胸腺细胞免疫球蛋白治疗再生障碍性贫血疗效显著,安全性高,具有一定的临床推广应用价值。
Objective To discuss the clinical effect of Yixuesheng Capsules combined with Rabbit Anti-human Thymocyte Immunoglobulin in treatment of aplastic anemia. Methods Patients（126 cases） with aplastic anemia in Tianjin Fifth Central Hospital from June 2015 to June 2016 were randomly divided into control（63 cases） and treatment（63 cases） groups. Patients in the control group were iv administered with Rabbit Anti-human Thymocyte Immunoglobulin, 2.5 mg/kg added into normal saline 250 mL, continuous instillation 4 h, once daily, and they were treated for 5 d. Patients in the treatment group were po administered with Yixuesheng Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the hematological parameters, the immunological indexes, and the adverse reactions two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 82.54%, which was significantly lower than 96.82% in the treatment group, and there were differences between two groups（P〈0.05）. After treatment, the leucocyte count, platelet count and hemoglobin level in two groups were significantly increased（P〈0.05）, and these indexes in the treatment group after treatment were significantly higher than those in the control group（P〈0.05）. After treatment, the CD4~＋ count in two groups were significantly increased（P〈0.05）, the CD8~＋ count were significantly decreased（P〈0.05）, and the immunological indexes in the treatment group after treatment were significantly better than those in the control group（P〈0.05）. During the treatment, the adverse reactions rate in the control group was 20.63%, which was significantly higher than 6.35% in the treatment group, with significant difference between two groups（P〈0.05）. Conclusion Yixuesheng Capsules combined with Rabbit Anti-human Thymocyte Immunoglobulin has significant curative effect in treatment of aplastic anemia with high safety, which has a certain clinical application value.
作者
张平
ZHANG Ping(Department of Hematology Oncology,Tianjin Fifth Central Hospital（Peking University Binhai Hospital）,Tianjin 300450,Chin)
出处
《现代药物与临床》
CAS
2018年第7期1751-1754,共4页
Drugs & Clinic
