摘要
目的调查多发性骨髓瘤(MM)化疗患者癌因性疲乏(CRF)发生情况,并探讨相关影响因素。方法选取2016年1月-2018年3月我院收治的134例MM化疗患者为研究对象,均完成一般资料、癌症疲乏量表(CFS)、疼痛视觉模拟量表(VAS)、汉密尔顿抑郁量表(HAMD)、心理弹性量表简化版(CD-RISC-10)、社会支持评定量表(SSRS)等调查。结果 134例MM化疗患者,情感疲乏得分为(5.91±1.79)分,躯体疲乏得分为(13.24±3.11)分,认知疲乏得分为(5.42±1.72)分,疲乏总得分为(24.41±6.58)分;CRF发生率为97.01%(130/134),以中度疲乏为主。单因素分析显示,不同性别、不同居住地、不同家庭人均月收入、不同治疗方式、是否达到完全缓解、有无重度贫血的MM化疗患者CRF得分比较,差异有统计学意义(P<0.05)。Pearson相关性分析显示,MM化疗患者CRF得分与疼痛、抑郁评分呈正相关(r=0.524、0.503,P<0.05),与心理弹性、社会支持评分均呈负相关(r=-0.512、-0.587,P<0.05)。多元Logistic回归分析显示,性别、家庭人均月收入、重度贫血、疼痛、抑郁、心理弹性、社会支持等均是MM化疗患者CRF的独立影响因素(P<0.05)。结论性别、家庭人均月收入、重度贫血、疼痛、抑郁、心理弹性、社会支持等均是MM化疗患者CRF的重要影响因素;临床可根据相关因素进行相应的护理干预,以预防或缓解CRF发生。
Objective To investigate the incidence of cancer-induced fatigue（ CRF） in patients with multiple myeloma（ MM） undergoing chemotherapy and the related influencing factors.Methods A total of 134 patients with MM undergoing chemotherapy who were admitted to the Department of Hematology of our hospital between January 2016 and March 2018 were selected as the subjects. The general data,Cancer Fatigue Scale（ CFS）,pain Visual Analogue Scale（ VAS）,Hamilton Depression Scale（ HAMD）,abbreviated version of Resilience Scale（ CD-RISC-10） and Social Support Rating Scale（ SSRS） were used for the investigation.Results Among the 134 patients with MM undergoing chemotherapy,the scores of emotional fatigue,physical fatigue,cognitive fatigue and the total fatigue score were（ 5.91± 1. 79） points,（ 13. 24 ± 3. 11） points,（ 5. 42 ± 1. 72） points and（ 24.41±6.58） points,respectively. The incidence of CRF was 97.01%（ 130/134）,and moderate fatigue was dominating. Univariate analysis showed that there were significant differences in CRF scores of patients with MM undergoing chemotherapy between patients who were different in gender,places of residence,per capita monthly income of the family,treatment methods,degrees of remission and severity of anemia（ P〈0.05）. Pearson correlation analysis showed that CRF scores were positively correlated with pain and depression scores in patients with MM undergoing chemotherapy（ r = 0.524,0.503,P〈0.05）,but negatively correlated with resilience and social support scores（ r =-0. 512,-0. 587,P 0. 05）. Multivariate Logistic regression analysis showed that gender,family per capita monthly income,severe anemia,pain,depression,resilience and social support were all independent influencing factors of CRF in patients with MM undergoing chemotherapy（ P〈0.05）. Conclusion Gender,family per capita monthly income,severe anemia,pain,depression,resilience and social support are important influencing factors of CRF in patients with MM undergoing chemotherapy. Clinical nursing interventions can be performed accordingly to prevent or reduce the occurrence of CRF.
作者
王莉
田静
熊冬梅
杜凌艳
谢晓燕
刘琴
曾吉
WANG Li;TIAN Jing;XIONG Dongmei;DU Lingyan;XIE Xiaoyan;LIU Qin;ZENG Ji(Department of Oneology and Hematology,People＇s Hospital of Leshan City,Leshan Siehuan 614000,China)
出处
《解放军预防医学杂志》
CAS
2018年第7期913-917,共5页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
四川省卫计委科研课题(No.130485)
关键词
多发性骨髓瘤
化疗
癌因性疲乏
影响因素
multiple myeloma
chemotherapy
cancer-related fatigue
influencing factors
