摘要
目的探讨分析子痫前期发病与缺氧诱导因子1α(Hif-1α)和胎盘生长因子(PLGF)表达异常的关系。方法选取60例子痫前期分为轻度子痫前期组和重度子痫前期组及30例正常妊娠者作为对照组,采取免疫组化法研究其胎盘组织中Hif-1α和PLGF的表达,分析二者与子痫前期发病的关系。结果子痫发病组胎盘组织中Hif-1α蛋白表达强度均比对照组高(P<0.05),而重度子痫前期组和轻度子痫前期组比较表达也明显升高(P<0.05)。子痫前期发病中胎盘组织PLGF表达强度均比对照组低(P<0.05),重度子痫前期组中PLGF表达与轻度子痫前期组相比,差异无统计学意义(P>0.05)。胎盘Hif-1α表达与PLGF的表达呈负相关的关系(r=-0.46,P<0.05)。结论胎盘Hif-1α和PLGF可作为血清标志物,其在子痫前期临床监测及诊治中具有一定的应用价值。
Objective To investigate the relationship between the pathogenesis of preeclampsia and the abnormal expression of hypoxia-inducible factor-1α（ Hif-1α） and placental growth factor（ PLGF）. Methods The expression of HIF-1α and PLGF in placenta tissue was analyzed by immunohistochemical method in 60 cases of preeclampsia patients and 30 normal pregnant women. Results The expression of HIF-1α protein in mild preeclampsia group and severe preeclampsia group was higher than that of control group（ all P〈0. 05）,while the expression of Hif-1α protein in severe preeclampsia group was significantly higher then mild pre-eclampsia group（ P〈0. 05）. The expression intensity of PLGF in mild preeclampsia group and severe preeclampsia group was lower than that of control group（ P〈0. 05）. There was no significant difference between severe and mild preeclampsia group（ P〉0. 05）. The expression of Hif-1α in placenta negatively correlated with the expression of PLGF（ r =-0. 46,P〈0. 05）. Conclusion The level of Hif-1α and PLGF in placenta could be used as an important serum marker,and it has certain application value in clinical monitoring and treatment preeclampsia.
作者
周小燕
余娟娟
ZHOU Xiao-yan, Yu Juan-juan(First Affiliated Hospital, Henan University of Science and Technology, Henan Luoyang 471003, Chin)
出处
《河南科技大学学报（医学版）》
2018年第2期84-86,共3页
Journal of Henan University of Science & Technology:Medical Science
基金
河南省医学科技攻关计划项目(201203078)
