摘要
目的:探讨人乳头瘤病毒(HPV)E6/E7 mRNA检测在30岁以下年轻女性宫颈疾病诊治中的应用。方法:选取2015年5月-2017年1月就诊于本院行细胞学检查发现的无明确诊断意义的鳞状上皮细胞病变(ASCUSAIL)患者100例,均为30岁以下年轻女性。按照随机数字表法将其分为对照组和研究组,各50例。对照组予传统HPV DNA分型检测,研究组直接进行HPV E6/E7 mRNA检测。比较两组病变预测准确度、特异度、阴道转诊率、患者满意度。结果:HPV E6/E7 mRNA检测诊断CINⅡ+准确度、特异度为72.00%、43.75%,均高于HPV DNA检测的64.00%、21.05%,比较差异均有统计学意义(P<0.05);HPV E6/E7 mRNA检测阴道转诊率为76.0%,低于HPV DNA检测的86.0%(P<0.05);HPV E6/E7 mRNA检测患者满意度为92.0%,高于HPV DNA检测的76.0%(P<0.05)。结论:HPV E6/E7mRNA检测诊断CINⅡ+较HPV DNA检测准确率高、阴道转诊率低、患者满意度高,对宫颈疾病的诊治有较好应用价值。
Objective：To investigate the application of human papillomavirus（HPV） E6/E7 mRNA in diagnosis and treatment of cervical diseases in young women under 30 years old.Method：A total of 100 ASCUSAIL patients who had been treated for cytological examination in our hospital from May 2015 to January 2017 were selected,they were young women under 30 years old.According to the random number table method,they were divided into control group and study group,50 cases in each group.The control group was given conventional HPV DNA typing test,and study group was directly tested by HPV E6/E7 mRNA.The accuracy,specificity,vaginal referral rate and patient satisfaction were compared between two groups.Result：The accuracy and specificity of CINⅡ＋ were 72.00% and 43.75% in the diagnosis of HPV E6/E7 mRNA,which were all higher than 64.00% and 21.05% of HPV DNA（P〈0.05）.The vaginal referral rate in HPV E6/E7 mRNA was 76.0% lower than 86.0% of HPV DNA（P〈0.05）.The patient satisfaction with HPV E6/E7 mRNA was 92.0% higher than 76.0% of HPV DNA（P〈0.05）.Conclusion：Compared with HPV DNA detection,HPV E6/E7 mRNA detection has high accuracy,low vaginal referral rate and high patient satisfaction,has good application value for the diagnosis and treatment of cervix disease.
作者
王武
叶凤如
WANG Wu;YE Fengru(Dalang Hospital of Dongguan,Dongguan 523770,Chin)
出处
《中国医学创新》
CAS
2018年第15期113-116,共4页
Medical Innovation of China
基金
东莞市医疗卫生一般项目(201610515000119)
