摘要
目的探讨孟鲁司特钠片联合布地奈德福莫特罗对支气管哮喘患者临床预后及生化指标的影响.方法选取本院在2016年1月至2016年7月期间收治的120例支气管哮喘急性发作患者作为研究对象,按照简单随机法分为两组,对照组予以布地奈德福莫特罗治疗;观察组予以孟鲁司特钠片联合布地奈德福莫特罗治疗.比较两组患者治疗效果、预后,以及治疗前后肺功能、生化指标变化.结果对照组治疗有效率为73.33%,观察组治疗有效率为91.67%,观察组患者治疗有效率明显高于对照组(P<0.05).两组患者在治疗后,FVC、FEV1、PEF等肺功能指标均有明显改善(P<0.05);观察组患者FVC、FEV1、PEF等肺功能指标检测结果明显优于对照组(P<0.05).观察组患者支气管哮喘急性发作次数、平均住院时间、平均住院次数低于对照组(P<0.05).两组患者治疗后IgA、IgE、IL-6、IL-8、TNF-α水平出现不同程度降低(P<0.05);观察组患者治疗后IgA、IgE、IL-6、IL-8、TNF-α水平低于观察组患者(P<0.05).结论孟鲁司特钠片联合布地奈德福莫特罗治疗支气管哮喘具有显著效果,改善患者肺功能及生化指标,患者预后较好.
Objective To investigate the effect of Montelukast sodium tablets combined with Budesonide and fol-noterol fumarate powder for inhalation on the clinical prognosis and biochemical indexes of bronchial asthma patients. Methods From January 2016 to July 2016, 120 cases of patients with bronchial asthma were studied in our hospital. According to the simple randmn method, they were divided into two groups, the control group was treated by Budesonide and formoterol fumarate powder tbr inha- lation, and the observation group was treated by Montelukast sodium tablets combined with Budesonide and formoterol fumarate powder for inhalation. The treatment effect, the prognosis, and the changes of lung function and biochemical indexes before and after treatment were compared between the two groups. Results The effective rate of the control group was 73.33%, the effec- tive rate of the observation group was 91.67%, and the effective rate of the observation group was significantly higher than that of the control group （ P〈0.05 ）. Two groups of patients after treatment, FVC, FEV1, PEF and other lung function indicators were significantly improved （P〈0. 05 ） ; the observation group patients FVC, FEV1, PEF and other indicators of lung function test re- suits were significantly better than the control group （P〈0. 05 ）. The tYequency of acute attack of bronchial asthma, the average time of hospitalization and the average number of hospitalization in the observation group were lower than that of the control group （P〈0. 05）. After treatment, the levels of IgA, IgE, IL-6, IL-8 and TNF- alpha in the two groups decreased to different de- grees （P〈0. 05）. The levels of IgA, IgE, IL-6, IL-8 and TNF- alpha in the observation group were lower than those in the ob- servation group after treatment （ P〈0. 05 ）. Conclusion Montelukast sodium tablets combined with Budesonide and formoterol fumarate powder for inhalation has significant effect in the treatment of bronchial asthma, improving the lung function and bio- chemical indexes of patients, and the prognosis of patients is better.
作者
李同林
刘蔺
周航
LI Tong-lin;LIU Lin;ZHOU Hang(Cherrgdu 363 Hospital, Sichuan , Chin)
出处
《中国地方病防治》
北大核心
2017年第12期1408-1409,共2页
Chinese Journal of Control of Endemic Diseases
基金
四川省卫生厅课题(编号:110874)
关键词
孟鲁司特钠片
布地奈德福莫特罗
支气管哮喘
Montelukast sodium tablets
Budesonide and formoterol fumarate powder for inhalation
Bronchial asthma
