摘要
妊娠期糖尿病不仅严重威胁母胎安全,导致不良妊娠结局,而且具有远期母子心血管代谢风险。妊娠期糖尿病病史母亲远期患发2型糖尿病、肥胖、高血压、代谢综合征、动脉粥样硬化等风险显著升高,是心血管疾病的危险因素;妊娠期宫内高血糖环境暴露导致子代发生肥胖、胰岛素抵抗、糖尿病、高血压、代谢综合征等心血管代谢性疾病的风险增加,是心血管疾病的源头和风险防范的重要机遇期。加强产、内科合作,提高妊娠期糖尿病母子心血管代谢风险的认识,对于保障母婴安全和重大慢病的防控至关重要。
Recent evidence have shown that gestational diabetes mellitus（GDM） not only is a threat to maternal and fetal safety, leading to adverse pregnant outcomes, but contributes to long-term maternal cardiometabolic risk both for the mothers and their offsprings. For mothers suffering from GDM, the risks for type 2 diabetes, obesity, hypertension, metabolic syndrome and arteriosclerosis are significantly increased, which are established risk factors for cardiovascular diseases（CVD）. Moreover, fetuses exposed to high-glucose during pregnancy are more likely to develop obesity, insulin resistance, diabetes, hypertension and metabolic syndrome during their adult lives. Therefore, GDM can be recognized as a developmental origin of adult CVD and also provides an opportunity for CVD prevention. To ensure maternal and fetal safety during pregnancy and to establish a new prevention and management strategy for the major non-communicable chronic diseases, it is of importance to enhance the collaborations between obstetrics and internal medicine, which would provide a platform for metabolic risk recognition in the mothers and their offsprings to ensure their safety.
作者
吴琳琳
牛建民
WU Lin-lin;NIU Jian-min(Department of Obstetrics, the Affiliated Shenzhen Maternal and Child Healthcare of Southern Medical University, Shenzhen 518028, China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2018年第6期527-530,共4页
Chinese Journal of Practical Internal Medicine
关键词
妊娠期糖尿病
子代
心血管代谢风险
预防
gestational diabetes mellitus
offspring
cardiometabolic risk
prevention
