摘要
目的探索不同舌苔胃癌患者的血清炎症因子的表达模式。方法临床收集134例不同舌苔的胃癌患者和93例不同舌苔的非胃癌人群,电化学发光免疫检测血清炎症因子水平,多因素关联分析舌苔类型和血清炎症因子的相关性。结果不同舌苔胃癌患者血清白细胞介素-17α(IL-17α)和肿瘤坏死因子-α(TNF-α)水平差异有统计学意义(P<0.05)。苔色分析发现,黄苔和白苔胃癌患者血清IL-17α水平中值分别为3.062和3.982 ng/L,差异有统计学意义(P<0.05),受试者工作特征曲线(ROC)分析显示血清IL-17α区分白苔与黄苔的灵敏度、特异性和计算线下区域面积(AUC)(95%CI)分别为72.7%、91.3%和0.639(0.539-0.739),截断值为6.033 ng/L,而且,类似的趋势在非胃癌人群中得到了验证。相关性分析显示,在同种舌苔胃癌患者内部,20种血清炎症因子显著正相关占主导地位,然而,在不同舌苔胃癌患者之间显著负相关占主导地位。结论血清IL-17α水平能够显著区分白苔和黄苔、白苔-黄苔、薄苔-厚苔可能反映了胃癌患者体内相反的炎症状态。
Objective To investigate the expressing patterns of serum inflammatory factors in patients with gastric cancer（GC） with different types of tongue fur. Methods GC patients with different types of longue fur（n = 134） and non-GC subjects with different types of tongue fur（n = 93） were chosen from clinic. The levels of serum inflammatory factors were detected by using electro-chemiluminescence immunoassay（ECLIA）,and correlation between types of tongue fur and serum inflammatory factors was analyzed by using multi-factor association method. Results The levels of serum interleukin-17α（IL-17α）had significant difference in GC patients with different types of longue fur（P 〈0. 05）. The analysis on fur color showed that level of serum IL-17α was 3. 062 ng/L in GC patients with yellow fur and 3. 982 ng/L in those with white fur（P 〈0. 05）. ROC analysis showed that the sensitivity was 72. 7%,specificity was 91. 3% and AUC（95% CI） was 0. 639（0. 539-0. 739） of serum IL-17α in distinguishing white fur and yellow fur,and cutoff value was 6. 033 ng/L. The similar tendency was identified in nonGC subjects. The correlation analysis showed that there were 20 serum inflammatory factors with significant positive correlation in GC patients with the same types of tongue fur,and significant negative correlation in GC patients with different types of tongue fur. Conclusion The level of IL-17α can significantly distinguish white tongue fur and yellow tongue fur. The white-yellow tongue fur and thin-thick tongue fur may reflect adverse inflammatory status in GC patients.
作者
张军峰
张李唯
吴娟
辛欠欠
董伟
王瑞平
詹瑧
Zhang Junfeng;Zhang Liwei;Wu Juan;Xin Qianqian;Dong Wei;Wang Ruiping;Zhan Zhen(School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Jiangsu 210023, China;Jiangsu Collaborative Inno- vation Center for Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Jiangsu 210023, China;Department of Oncology, Jiangsu Hospital of Traditional Chinese Medicine, Jiangsu 210029, China)
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2018年第5期405-412,共8页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(No.81473458
No.81473593)
国家中医临床研究基地业务建设科研专项资助项目(No.JDZX2015089)
江苏干部保健科研课题资助项目(No.BJ14013)~~
关键词
胃癌
舌苔
炎症因子
表达模式
gastric cancer
tongue fur
inflammatory factors
expressing patterns
