摘要
目的探讨盐酸拉贝洛尔联合丹参注射液对妊娠期高血压患者的临床疗效及安全性。方法选取2015年11月—2017年4月平顶山市第一人民医院收治的78例妊娠期高血压患者,通过随机数字表法分为对照组与研究组各39例,所有患者均予以降血压等所患疾病常规对症治疗,对照组在此基础上采用盐酸拉贝洛尔治疗,研究组采用盐酸拉贝洛尔+丹参注射液治疗,2组均持续治疗10 d,治疗结束后统计对比2组临床疗效、入院时及疗程结束后血压[舒张压(DBP)、收缩压(SBP)]、血清β2-MG、Hcy水平变化情况、母婴结局、不良反应发生率。结果治疗后研究组和对照组临床总有效率比较(94.87%vs 74.36%)差异有统计学意义(χ~2=6.303,P=0.012);治疗后2组DBP、SBP均较治疗前降低,且研究组DBP、SBP水平降低程度显著大于对照组(t=15.760,P<0.001;t=10.708,P<0.001);治疗后2组血清β2-MG、Hcy水平较治疗前降低,且研究组血清β2-MG、Hcy水平均较对照组降低明显(t=21.121,P<0.001;t=22.803,P<0.001);研究组不良妊娠结局率(23.08%)明显低于对照组(46.15%)(χ2=4.058,P=0.032);研究组不良反应发生率(15.38%)与对照组(10.26%)比较差异无统计学意义(χ~2=0.459,P=0.498)。结论盐酸拉贝洛尔联合丹参注射液可明显降低妊娠期高血压患者血压、血清Hcy、β2-MG水平及母婴不良结局率,具有较高的有效率和一定的安全性,值得临床上推广使用。
Objective To investigate the clinical efficacy and safety of Labetalol Hydrochloride combined with salvia mihi- orrhiza injection in treatment of patients with gestational period hypertension. Methods Total 78 cases of gestational period hypertension in our hospital from November, 2015 to April, 2017 were randomly divided into control group （n = 39） and study group （ n= 39） according to random number table. The control group was treated with labetalol hydrochloride and the study group was treated with labetalol hydrochloride combined with salvia mihiorrhiza injection. The course was 10 days. The clinical efficacy, DBP, SBP, serum β2-MG and Hcy levels, the maternal and infant outcomes and rate of adverse reac- tions were compared between two groups. Results The total effective rate of the study group was 94.87%, which was higher than that in the control group （74.36%）, P 〈 0.05. After the treatment, the DBP and SBP in the two groups were decreased, and the changed degree of DBP and SBP in study group were lower than those in control group （t = 15. 760, P 〈 0. 001, t = 10. 708, P 〈0. 001 ）. After the treatment, the level of β2-MG and Hcy in two group were decreased compared with before treatment, and the decreased degree of study group was lower than those in control group （ t = 21. 121, P 〈0. 001 , t =22.803, P 〈0.001 ）. The rate of adverse pregnancy outcome in study group （23.08%） was lower than that in control group （46.15%, χ2 =4.588, P =0.032）. The incidences of adverse reactions in study group （ 15.38% ） was not statistically significant compared with the control group （ 10.26% ） , χ2 = 0.459, P = 0. 458. Conclusion Labetalol hydrochloride combined with Salvia mihiorrhiza injection in the treatment of gestational period hypertension can effectively reduce the blood pressure, improve the treatment effect, improve serum Hcy, β2-MG levels and maternal and child out- comes. It has high efficiency and safety, and is worthy of clinical promotion.
作者
魏娜
毛亚平
商倩楠
WEI Na;MAO Ya-ping;SHANG Qian-nan(Department of Obstetrics, the First People＇ s Hospital of Pingdingshan, Pingdingshan, Henan 467000, Chin)
出处
《中华全科医学》
2018年第7期1144-1147,共4页
Chinese Journal of General Practice
基金
河南省医学科技攻关计划项目(201505326)
