摘要
目的探讨前列腺癌(PCa)患者的免疫功能指标变化及不同临床特征对免疫功能指标水平的影响。方法选取60例PCa患者(PCa组)、30例良性前列腺增生(BPH)患者(BPH组)和20例健康体检者(健康组),检测所有受试者外周血中CD4^+、CD8^+、NK、CD4^+/CD8^+的水平并分析PCa患者不同分化程度、临床分期、有无肿瘤转移及内分泌治疗等临床特征对免疫功能的影响。结果 3组CD4^+、CD8^+、CD4^+/CD8^+水平比较,差异均有统计学意义(P<0.01);3组NK水平比较,差异无统计学意义(P>0.05)。PCa组CD4^+、CD4^+/CD8^+水平均低于BPH组、健康组,CD8^+水平高于BPH组、健康组,差异均有统计学意义(P<0.05)。高分化的PCa患者CD4^+、CD4^+/CD8^+水平均高于中低分化患者,CD8^+水平低于中低分化患者,差异均有统计学意义(P<0.05);有肿瘤转移的PCa患者CD4^+、CD4^+/CD8^+水平均低于无肿瘤转移患者,CD8^+水平高于无肿瘤转移患者,差异均有统计学意义(P<0.05);而不同临床分期、内分泌治疗情况的PCa患者的CD4^+、CD8^+、NK、CD4^+/CD8^+水平比较,差异均无统计学意义(P>0.05)。结论 PCa患者的免疫功能明显低于BPH患者和健康体检者,且肿瘤的分化程度越高,转移潜能越大,患者的免疫功能越低。
Objective To investigate the effect of different clinical features on immune function indexes in patients with prostate cancer（PCa）. Method 60 cases of PCa patients（PCa group）, 30 cases of benign prostatic hyperplasia（BPH group） and 20 healthy subjects（normal group） were included in the study, and were detected for CD4^＋, CD8^＋, NK,CD4^＋/CD8^＋ in peripheral blood, to investigate the effect of the degree of differentiation, clinical stage, presence of metastasis, and administration of endocrine therapy on the change of immune function. Result The CD4^＋, CD8^＋, CD4^＋/CD8^＋ levels were significantly different among the three groups（P〈0.01）; three groups had similar NK level, without statistically significant difference observed（P〉0.05）. In PCa group, the CD4^＋, CD4^＋/CD-8＋ levels were lower than that in BPH group and normal group, while CD8^＋ level was higher, demonstrating statistically significant difference（P〈0.05）. Patients in PCa group with highly differentiated disease were with higher levels of CD4^＋, CD4^＋/CD8^＋, while CD8^＋ level was lower than those with poor or moderate differentiations, showing statistically significant differences（P〈0.05）; in PCa group, metastasis was associated with lower CD4^＋, CD4^＋/CD8^＋, and higher CD8^＋ compared with those without metastasis, the difference was statistically significant（P〈0.05）; but CD4^＋, CD8^＋, NK, CD4^＋/CD8^＋ were independent of clinical stage and administration of endocrine therapy（P〉0.05）. Conclusion The immune function of prostate cancer patients is lower than that of normal population and BPH patients, and higher differentiation degree is associated with greater metastatic potential, indicating poorer immune function of patients with prostate cancer.
作者
罗林
王海洋
邱凌
聂文辉
LUO Lin;WANG Haiyang;QIU Ling;NIE Wenhui(Department of Urological Surgery, Sichuan Petroleum General Hospital, Chengdu 610213, Sichuan, China)
出处
《癌症进展》
2018年第4期509-511,共3页
Oncology Progress
关键词
前列腺癌
免疫功能
内分泌治疗
临床特征
prostate cancer
immune function
endocrine therapy
clinical feature
